Target Information

General Information of This Target
Target ID
BTDT10250
Target Name
ShakerKD
Target Bioclass
Transporter and channel
Taxonomy ID
7227
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Drosophilidae
Genus: Drosophila
Species: Drosophila melanogaster
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conk-S1 (E20A) Effective concentration 50
0.26 nM
 [1]
 Toxin Info    Conk-S1 (D8A) Effective concentration 50
0.34 nM
 [1]
 Toxin Info    Conk-S1 (P4G) Effective concentration 50
0.49 nM
 [1]
 Toxin Info    Conk-S1 (R3A) Effective concentration 50
0.57 nM
 [1]
 Toxin Info    Conk-S1 (K1A) Effective concentration 50
0.95 nM
 [1]
 Toxin Info    Kunitz-type conkunitzin-S1 Effective concentration 50
0.95 nM
 [2], [3], [4]
 Toxin Info    Conk-S1 (R22A) Effective concentration 50
1.23 nM
 [1]
 Toxin Info    Conk-S1 (K18A) Effective concentration 50
1.29 nM
 [1]
 Toxin Info    Conk-S1 (T50A) Effective concentration 50
1.51 nM
 [1]
 Toxin Info    Conk-S1 (R48A) Effective concentration 50
2 nM
 [1]
 Toxin Info    Conk-S1 (R29A) Effective concentration 50
2.1 nM
 [1]
 Toxin Info    Conk-S1 (K21D) Effective concentration 50
2.81 nM
 [1]
 Toxin Info    Conk-S1 (Q54A) Effective concentration 50
3.57 nM
 [1]
 Toxin Info    Conk-S1 (R48D) Effective concentration 50
3.66 nM
 [1]
 Toxin Info    Conk-S1 (R29D) Effective concentration 50
3.8 nM
 [1]
 Toxin Info    Conk-S1 (K30A) Effective concentration 50
4.3 nM
 [1]
 Toxin Info    Conk-S1 (K21A) Effective concentration 50
5 nM
 [1]
 Toxin Info    Conk-S1 (R55A) Effective concentration 50
11.4 nM
 [1]
 Toxin Info    Conk-S1 (Y51A) Effective concentration 50
11.9 nM
 [1]
 Toxin Info    Conk-S1 (Y30D) Effective concentration 50
13.8 nM
 [1]
 Toxin Info    Conk-S1 (R49A) Effective concentration 50
15.6 nM
 [1]
 Toxin Info    Conk-S1 (R34A) Effective concentration 50
25 nM
 [1]
 Toxin Info    Conk-S1 (R55D) Effective concentration 50
132 nM
 [1]
 Toxin Info    Conk-S1 (R22D) Effective concentration 50
294 nM
 [1]
 Toxin Info    Conk-S1 (Y51E) Effective concentration 50
611 nM
 [1]
 Toxin Info    Conk-S1 (Y59A) Effective concentration 50
1.017 μM
 [1]
 Toxin Info    Conk-S1 (R34D) Effective concentration 50
1.048 μM
 [1]
 Toxin Info    Toxin kappa-KTx 2.6 IC50
2 μM
 [5]
References
Ref 1 Pore-modulating toxins exploit inherent slow inactivation to block K(+) channels. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18700-18709. doi: 10.1073/pnas.1908903116. Epub 2019 Aug 23.
Ref 2 Production of recombinant Conkunitzin-S1 in Escherichia coli. Protein Expr Purif. 2006 Jun;47(2):640-4. doi: 10.1016/j.pep.2006.01.019. Epub 2006 Feb 20.
Ref 3 Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J Biol Chem. 2005 Jun 24;280(25):23766-70. doi: 10.1074/jbc.C500064200. Epub 2005 Apr 15.
Ref 4 Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):980-90. doi: 10.1107/S0907444906021123. Epub 2006 Aug 19.
Ref 5 A Molecular Lid Mechanism of K(+) Channel Blocker Action Revealed by a Cone Peptide. J Mol Biol. 2021 Aug 20;433(17):166957. doi: 10.1016/j.jmb.2021.166957. Epub 2021 Mar 24.
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