Peptide Information

General Information of This Peptide
Peptide ID
BTDP008707
Peptide Name
Potassium channel toxin alpha-KTx 21.1
Symonym
Tityustoxin-15
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KA211_TITSE
Alphafold ID
P86270
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P86270
Sequence
MQFSGVVLILISMTLVNFVFFETKVEAGKFGKCKPNICAKTCQTEKGKGMGYCNKTECVC
SEW
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Sequence Length
63
Mass (Da)
7007
Sequence Removed Signal Peptide
GKFGKCKPNICAKTCQTEKGKGMGYCNKTECVCSEW
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Disulfide Bond
33-53;38-58;42-60
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    ERG Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv1.1 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv1.4 Inhibition rate .
500 nM
Blocker
 [3]
 Target Info    Kv1.4 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv2.1 Inhibition rate .
500 nM
Blocker
 [3]
 Target Info    Kv2.1 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Nav1.4 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv1.5 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv3.1 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv11 Inhibition rate .
500 nM
Blocker
 [3]
 Target Info    Nav1.5 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv4.3 Inhibition rate .
500 nM
Blocker
 [3]
 Target Info    Kv4.3 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Nav1.8 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv4.2 Inhibition rate .
500 nM
Blocker
 [3]
 Target Info    Kv4.2 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Nav1.6 Inhibition rate .
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv3.1 Inhibition rate
5 %
500 nM
Blocker
 [3]
 Target Info    Kv1.5 Inhibition rate
10 %
500 nM
Blocker
 [3]
 Target Info    Kv1 Inhibition rate
10 %
500 nM
Blocker
 [3]
 Target Info    Shaker Inhibition rate
20 %
500 nM
Blocker
 [3]
 Target Info    Kv1.6 Inhibition rate
20 %
500 nM
Blocker
 [3]
 Target Info    Kv1.6 Inhibition rate
22 %
0.5 μM
Blocker
 [1- 5]
 Target Info    Shaker-IR Inhibition rate
30 %
0.5 μM
Blocker
 [1- 5]
 Target Info    Kv1.2 IC50
196 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.2 IC50
196 nM
 .
Blocker
 [1- 5]
 Target Info    Kv1.3 IC50
508 nM
 .
Blocker
 [3]
 Target Info    Kv1.3 IC50
508 nM
 .
Blocker
 [1- 5]
References
Ref 1 Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One. 2018 Mar 21;13(3):e0193739. doi: 10.1371/journal.pone.0193739. eCollection 2018.
Ref 2 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 3 Purification and characterization of Ts15, the first member of a new -KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus. Toxicon. 2011 Jul;58(1):54-61. doi: 10.1016/j.toxicon.2011.05.001. Epub 2011 May 13.
Ref 4 Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus. J Proteome Res. 2013 Jul 5;12(7):3460-70. doi: 10.1021/pr4003068. Epub 2013 Jun 13.
Ref 5 Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity. Toxicon. 2014 Nov;90:326-36. doi: 10.1016/j.toxicon.2014.08.064. Epub 2014 Sep 6.
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