Peptide Information

General Information of This Peptide
Peptide ID
BTDP008660
Peptide Name
Potassium channel toxin alpha-KTx 3.7
Symonym
OsK-1
Species
Orthochirus scrobiculosus (Central Asian scorpion)
Uniprot Name
KAX37_ORTSC
Alphafold ID
P55896
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1SCO
Sequence
GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK
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Sequence Length
38
Mass (Da)
4211
Sequence Removed Signal Peptide
GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK
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Disulfide Bond
8-28;14-33;18-35
PDB ID
1SCO , 2CK4 , 2CK5
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Orthochirus
Species: Orthochirus scrobiculosus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.6 Inhibition rate .
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [5]
 Target Info    Kv3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [5]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.7 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv3.2 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    KCa2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
100 %
1 μM
Blocker
 [5]
 Target Info    Kv1.3 IC50
0.014 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.014 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1 IC50
0.6 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
0.6 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 IC50
5.4 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 IC50
5.4 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
6 nM
 .
Blocker
 [5]
 Target Info    Kv1.6 IC50
71 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1 IC50
72 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    KCa3.1 IC50
225 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    KCa3.1 IC50
225 nM
 .
Blocker
 [1]
 Target Info    muscle-type nAChR IC50
1.6 μM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. doi: 10.1042/BJ20041379.
Ref 2 Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol. 2006 Jan;69(1):354-62. doi: 10.1124/mol.105.017210. Epub 2005 Oct 18.
Ref 3 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 4 Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom. Biochemistry. 1997 Feb 11;36(6):1223-32. doi: 10.1021/bi9614390.
Ref 5 Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels. Sci Rep. 2016 Sep 21;6:33314. doi: 10.1038/srep33314.
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