Target Information

General Information of This Target
Target ID
BTDT00037
Target Name
Acetylcholine receptor subunit gamma (chrng)
Target Bioclass
Receptor
Uniprot ID
P05376
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
chrng
Sequence
MDTVLLLVSLCISAAFCNNEEERLLNDLMKNYNKNLRPVEKDGDIISVSIKLTLTNLISL
NEKEEALTTNVWVEMQWKDYRLSWDPNDYHGISMMRIPSTSVWLPDVGLENNVDGTFDIA
LYTNTLVSSDGSMYWLPPAIYRSSCPVVVTYFPFDWQNCSIVFQSQTYSANEIELLLTVD
EQTIEWIEIDPEAFTENGEWAIKHMPAKRIINHRLPRDDVNYQQIVFYLIIQRKPLFYII
NIIVPCVLISFVSILVYFLPAKAGGQKCTVSINILLAQTVFLFLVAQKIPETSTSVPLIV
KYLTFLMVVTITIVANAVIVLNISLRTPNTHSMSSTVRELCLRTVPRLLRMHLRPTDAAP
PLAPLMRRSSSLGLMMKADEYMLRKPRSQLMFEKQKERDGLMKVVLDKIGRGMENNTSDD
LVHSLNHAAPEIRTCVEACCHIASATREKNDFKSENEEWILMGRVIDRVCFLVMCFVFFL
GTIGTFLAGHFNQAPAHPFPGDSKLYQPST

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Family
the ligand-gated ion channel (TC 1.A.9) family
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

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Taxonomy ID
8355
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Kingdom: Metazoa
Phylum: Chordata
Class: Amphibia
Order: Anura
Family: Pipidae
Genus: Xenopus
Species: Xenopus laevis
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Potassium channel toxin alpha-KTx 3.7 IC50
1.6 μM
 [1], [2], [3], [4]
References
Ref 1 K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. doi: 10.1042/BJ20041379.
Ref 2 Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain. Mol Pharmacol. 2006 Jan;69(1):354-62. doi: 10.1124/mol.105.017210. Epub 2005 Oct 18.
Ref 3 Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18.
Ref 4 Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom. Biochemistry. 1997 Feb 11;36(6):1223-32. doi: 10.1021/bi9614390.
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