Peptide Information

General Information of This Peptide
Peptide ID
BTDP008584
Peptide Name
Potassium channel toxin AbeTx1
Species
Actinia bermudensis (Maroon anemone)
Uniprot Name
K6TX1_ACTBE
Alphafold ID
C0HJD9
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJD9
Sequence
RCKTCSKGRCRPKPNCG
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Sequence Length
17
Mass (Da)
1894
Sequence Removed Signal Peptide
RCKTCSKGRCRPKPNCG
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Disulfide Bond
2-16;5-10
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Actinia
Species: Actinia bermudensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Nav1.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Nav1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    BgNav1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
15 %
3 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
15 %
3 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
20 %
3 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
20 %
3 μM
Blocker
 [1]
 Target Info    Kv1.6 IC50
115.68 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
116 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
167 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
167.36 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
671.95 nM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
672 nM
 .
Blocker
 [1]
References
Ref 1 AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K? Channels Activation. Mar Drugs. 2018 Oct 1;16(10):360. doi: 10.3390/md16100360.
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