Peptide Information

General Information of This Peptide
Peptide ID
BTDP008567
Peptide Name
U-actitoxin-Oulsp1
Symonym
OspTx2a
Species
Oulactis sp. (Sea anemone)
Uniprot Name
K1B1_OULSP
Alphafold ID
A0A330KW27
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6CKD
Sequence
MNTKLVVVFLLSAILFVSVTASRPGKDLERDEAYETYDDENKRACKDVFPAATCRHAKSV
GNCSSEKYKRNCAITCGAC
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Sequence Length
79
Mass (Da)
8711
Signal Sequence
MNTKLVVVFLLSAILFVSVTA
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Sequence Removed Signal Peptide
SRPGKDLERDEAYETYDDENKRACKDVFPAATCRHAKSVGNCSSEKYKRNCAITCGAC
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Disulfide Bond
45-79;54-72;63-76
PDB ID
6CKD , 6CKF
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Oulactis
Species: Oulactis sp. MM-2018
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv11.1 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Shaker-IR Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Shaker-IR Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv1 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv1.5 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv4.1 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv3.1 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv10 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv10 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv2.1 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv4.2 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
10 μM
Blocker
 [2]
 Target Info    Kv1.2 IC50
1.778 μM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
1.8 - 2.5 μM
 .
Blocker
 [2]
 Target Info    Kv1.6 IC50
5.6 - 6.2 μM
 .
Blocker
 [2]
 Target Info    Kv1.6 IC50
6.542 μM
 .
Blocker
 [1]
References
Ref 1 Sunanda, Punnepalli, et al. "Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp." Peptide Science 110.4 (2018): e24073.
Ref 2 Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK. Peptides. 2018 Jan;99:169-178. doi: 10.1016/j.peptides.2017.10.001. Epub 2017 Oct 6.
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