Peptide Information

General Information of This Peptide
Peptide ID
BTDP008534
Peptide Name
Potassium channel toxin epsilon-KTx 1.1
Symonym
Tityustoxin-11; TsPep1
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KEX11_TITSE
Alphafold ID
P0C174
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2MSF
Sequence
MKLSCGFLLILLVLSAMIATFSEVEAMKPSKPKCGLCRYRCCSGGCSSGKCVNGACDCSG
RSDLNDELEKYQ
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Sequence Length
72
Mass (Da)
7721
Signal Sequence
MKLSCGFLLILLVLSAMIATFSEVEA
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Sequence Removed Signal Peptide
MKPSKPKCGLCRYRCCSGGCSSGKCVNGACDCSGRSDLNDELEKYQ
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Disulfide Bond
34-42;37-58;41-51;46-56
PDB ID
2MSF
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
10 %
3 μM
Blocker
 [1- 5]
 Target Info    Shaker-IR Inhibition rate
10 %
3 μM
Blocker
 [1]
 Target Info    Kv11/ERG Inhibition rate
12 %
3 μM
Blocker
 [1- 5]
 Target Info    Kv11 Inhibition rate
12 %
3 μM
Blocker
 [1]
 Target Info    Kv11.1 Inhibition rate
15 %
3 μM
Blocker
 [1- 5]
 Target Info    Kv10 Inhibition rate
15 %
3 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
25 %
3 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
25 %
3 μM
Blocker
 [1- 5]
 Target Info    Kv4.2 Inhibition rate
25 %
3 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate
25 %
3 μM
Blocker
 [1- 5]
 Target Info    Kv1.3 Inhibition rate
27 %
3 μM
Blocker
 [1- 5]
 Target Info    Kv1.3 IC50
17.1 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
17.1 μM
 .
Blocker
 [1- 5]
References
Ref 1 Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins. Toxins (Basel). 2016 Sep 30;8(10):288. doi: 10.3390/toxins8100288.
Ref 2 Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One. 2018 Mar 21;13(3):e0193739. doi: 10.1371/journal.pone.0193739. eCollection 2018.
Ref 3 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 4 Novel structural class of four disulfide-bridged peptides from Tityus serrulatus venom. Biochem Biophys Res Commun. 2003 Feb 21;301(4):1086-92. doi: 10.1016/s0006-291x(03)00082-2.
Ref 5 Tityus serrulatus scorpion venom and toxins: an overview. Protein Pept Lett. 2009;16(8):920-32. doi: 10.2174/092986609788923329.
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