Target Information

General Information of This Target
Target ID
BTDT10089
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-1-beta-1-delta
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-conotoxin TxIA Inhibition rate . [1], [2]
 Toxin Info    Candoxin IC50
10 nM
 [3], [4], [5]
 Toxin Info    Three-finger toxin A1 IC50
12 nM
 [6]
 Toxin Info    Alpha-conotoxin OI IC50
16.9 nM
 [7]
 Toxin Info    Alpha-conotoxin OI IC50
102.8 nM
 [7]
 Toxin Info    Alpha-conotoxin SII IC50
120 nM
 [8- 13]
 Toxin Info    Alpha-conotoxin SI IC50
142 nM
 [8- 16]
 Toxin Info    Three-finger toxin 3b IC50
2.56 μM
 [17]
 Toxin Info    Fulditoxin IC50
2.56 μM
 [17], [18], [19]
 Toxin Info    Alpha-conotoxin MilIA IC50
11 μM
 [20]
References
Ref 1 AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. 2007 Aug 22;26(16):3858-67. doi: 10.1038/sj.emboj.7601785. Epub 2007 Jul 26.
Ref 2 Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon. 2012 Dec 15;60(8):1370-9. doi: 10.1016/j.toxicon.2012.09.013. Epub 2012 Sep 29.
Ref 3 Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta ) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors. J Biol Chem. 2002 May 17;277(20):17811-20. doi: 10.1074/jbc.M111152200. Epub 2002 Mar 7.
Ref 4 Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus). Br J Pharmacol. 2003 Jun;139(4):832-44. doi: 10.1038/sj.bjp.0705299.
Ref 5 Crystallization and preliminary X-ray analysis of candoxin, a novel reversible neurotoxin from the Malayan krait Bungarus candidus. Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):584-6. doi: 10.1107/s0907444903001094. Epub 2003 Feb 21.
Ref 6 Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (Squamata: Elapidae). Toxicon. 2013 May;66:64-74. doi: 10.1016/j.toxicon.2013.02.006. Epub 2013 Feb 22.
Ref 7 Research into the Bioengineering of a Novel -Conotoxin from the Milked Venom of Conus obscurus. Int J Mol Sci. 2022 Oct 11;23(20):12096. doi: 10.3390/ijms232012096.
Ref 8 Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides. 1999;20(10):1139-44. doi: 10.1016/s0196-9781(99)00116-3.
Ref 9 cDNA cloning of two A-superfamily conotoxins from Conus striatus. Toxicon. 2003 Nov;42(6):613-9. doi: 10.1016/j.toxicon.2003.08.005.
Ref 10 The A-superfamily of conotoxins: structural and functional divergence. J Biol Chem. 2004 Apr 23;279(17):17596-606. doi: 10.1074/jbc.M309654200. Epub 2003 Dec 30.
Ref 11 Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26. doi: 10.1021/bi00156a009.
Ref 12 Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study. Anal Biochem. 2005 Mar 1;338(1):48-61. doi: 10.1016/j.ab.2004.10.001.
Ref 13 Cysteine-Rich -Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chem Neurosci. 2022 Apr 20;13(8):1245-1250. doi: 10.1021/acschemneuro.1c00857. Epub 2022 Mar 31.
Ref 14 Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI. Biochemistry. 1988 Sep 6;27(18):7102-5. doi: 10.1021/bi00418a065.
Ref 15 Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74. doi: 10.1021/bi970195w.
Ref 16 Solution structure of alpha-conotoxin SI. FEBS Lett. 2000 Jul 7;476(3):287-95. doi: 10.1016/s0014-5793(00)01724-5.
Ref 17 The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms. BMC Genomics. 2013 Aug 2;14:531. doi: 10.1186/1471-2164-14-531.
Ref 18 Post-transcriptional Mechanisms Contribute Little to Phenotypic Variation in Snake Venoms. G3 (Bethesda). 2015 Sep 9;5(11):2375-82. doi: 10.1534/g3.115.020578.
Ref 19 Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. Br J Pharmacol. 2020 Apr;177(8):1822-1840. doi: 10.1111/bph.14954. Epub 2020 Feb 9.
Ref 20 Structure-Function Elucidation of a New -Conotoxin, MilIA, from Conus milneedwardsi. Mar Drugs. 2019 Sep 16;17(9):535. doi: 10.3390/md17090535.
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