Peptide Information

General Information of This Peptide
Peptide ID
BTDP008246
Peptide Name
Fulditoxin
Symonym
Micrurus fulvius dimeric neurotoxin; SIGMA-neurotoxin; Three-finger toxin 3a; Three-finger toxin 9a; Three-finger toxin 9d; Three-finger toxin 9e
Species
Micrurus fulvius (Eastern coral snake) (Coluber fulvius)
Uniprot Name
3SXA_MICFL
Alphafold ID
U3FAE1
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 4RUD
Sequence
MKTLLLTLVVVTIVCLDLGNSLKCYSSRTETMTCPEGEDKCEKYAVGLMHGSFFFIYTCT
SKCHEGAYNVCCSTDLCNKSSTSG
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Sequence Length
84
Mass (Da)
9183
Signal Sequence
MKTLLLTLVVVTIVCLDLGNS
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Sequence Removed Signal Peptide
LKCYSSRTETMTCPEGEDKCEKYAVGLMHGSFFFIYTCTSKCHEGAYNVCCSTDLCNKSS
TSG
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Disulfide Bond
24-41;34-59;63-71;72-77
PDB ID
4RUD
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Micrurus
Species: Micrurus fulvius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-4-beta-2 IC50
1.8 μM
 . . [1], [2], [3]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
2.56 μM
 . . [1], [2], [3]
 Target Info    nAChR alpha-7 IC50
7 μM
 . . [1], [2], [3]
 Target Info    nAChR alpha-3-beta-2 IC50
12.6 μM
 . . [1], [2], [3]
References
Ref 1 The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms. BMC Genomics. 2013 Aug 2;14:531. doi: 10.1186/1471-2164-14-531.
Ref 2 Post-transcriptional Mechanisms Contribute Little to Phenotypic Variation in Snake Venoms. G3 (Bethesda). 2015 Sep 9;5(11):2375-82. doi: 10.1534/g3.115.020578.
Ref 3 Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. Br J Pharmacol. 2020 Apr;177(8):1822-1840. doi: 10.1111/bph.14954. Epub 2020 Feb 9.
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