Peptide Information

General Information of This Peptide
Peptide ID
BTDP008244
Peptide Name
Three-finger toxin 3b
Symonym
Micrurus fulvius dimeric neurotoxin b; SIGMA-neurotoxin
Species
Micrurus fulvius (Eastern coral snake) (Coluber fulvius)
Uniprot Name
3SXB_MICFL
Alphafold ID
U3EPL2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: U3EPL2
Sequence
MKTLLLTLVVVTIVCLDLGNSLKCYSSRTETMTCPEGEDKCEKYAAGLMHGSFFFIYTCT
SKCHEGAYNVCCSTDLCNKSSTSG
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Sequence Length
84
Mass (Da)
9155
Signal Sequence
MKTLLLTLVVVTIVCLDLGNS
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Sequence Removed Signal Peptide
LKCYSSRTETMTCPEGEDKCEKYAAGLMHGSFFFIYTCTSKCHEGAYNVCCSTDLCNKSS
TSG
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Disulfide Bond
24-41;34-59;63-71;72-77
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Micrurus
Species: Micrurus fulvius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-4-beta-2 IC50
1.8 μM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
2.56 μM
 . . [1]
 Target Info    nAChR alpha-7 IC50
7 μM
 . . [1]
 Target Info    nAChR alpha-3-beta-2 IC50
12.6 μM
 . . [1]
References
Ref 1 The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms. BMC Genomics. 2013 Aug 2;14:531. doi: 10.1186/1471-2164-14-531.
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