Peptide Information

General Information of This Peptide
Peptide ID
BTDP005899
Peptide Name
Alpha-conotoxin SII
Species
Conus striatus (Striated cone)
Uniprot Name
CAS2_CONST
Alphafold ID
P28879
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6OTB
Sequence
MGMRMMFTVFLLVVLATTVVSFPSDRASDGRDDEAKDERSDMHESDRNGRGCCCNPACGP
NYGCGTSCSRTL
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Sequence Length
72
Mass (Da)
7830
Signal Sequence
MGMRMMFTVFLLVVLATTVVS
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Sequence Removed Signal Peptide
FPSDRASDGRDDEAKDERSDMHESDRNGRGCCCNPACGPNYGCGTSCSRTL
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Disulfide Bond
52-68;53-58;54-64
PDB ID
6OTB , 6OVJ
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
120 nM
 .
Adult subtype
 [1- 6]
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
370 nM
 .
Fetal subtype
 [1- 6]
References
Ref 1 Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides. 1999;20(10):1139-44. doi: 10.1016/s0196-9781(99)00116-3.
Ref 2 cDNA cloning of two A-superfamily conotoxins from Conus striatus. Toxicon. 2003 Nov;42(6):613-9. doi: 10.1016/j.toxicon.2003.08.005.
Ref 3 The A-superfamily of conotoxins: structural and functional divergence. J Biol Chem. 2004 Apr 23;279(17):17596-606. doi: 10.1074/jbc.M309654200. Epub 2003 Dec 30.
Ref 4 Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26. doi: 10.1021/bi00156a009.
Ref 5 Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study. Anal Biochem. 2005 Mar 1;338(1):48-61. doi: 10.1016/j.ab.2004.10.001.
Ref 6 Cysteine-Rich -Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chem Neurosci. 2022 Apr 20;13(8):1245-1250. doi: 10.1021/acschemneuro.1c00857. Epub 2022 Mar 31.
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