Peptide Information

General Information of This Peptide
Peptide ID
BTDP006427
Peptide Name
Candoxin
Species
Bungarus candidus (Malayan krait)
Uniprot Name
3NO4_BUNCA
Alphafold ID
P81783
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1JGK
Sequence
MKTLLLTLVVVTIVCLDLGYTMKCKICNFDTCRAGELKVCASGEKYCFKESWREARGTRI
ERGCAATCPKGSVYGLYVLCCTTDDCN
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Sequence Length
87
Mass (Da)
9635
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
MKCKICNFDTCRAGELKVCASGEKYCFKESWREARGTRIERGCAATCPKGSVYGLYVLCC
TTDDCN
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Disulfide Bond
24-47;27-32;40-64;68-80;81-86
PDB ID
1JGK
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Bungarus
Species: Bungarus candidus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
10 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-7 IC50
50 nM
 . . [1], [2], [3]
References
Ref 1 Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta ) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors. J Biol Chem. 2002 May 17;277(20):17811-20. doi: 10.1074/jbc.M111152200. Epub 2002 Mar 7.
Ref 2 Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus). Br J Pharmacol. 2003 Jun;139(4):832-44. doi: 10.1038/sj.bjp.0705299.
Ref 3 Crystallization and preliminary X-ray analysis of candoxin, a novel reversible neurotoxin from the Malayan krait Bungarus candidus. Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):584-6. doi: 10.1107/s0907444903001094. Epub 2003 Feb 21.
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