Peptide Information

General Information of This Peptide
Peptide ID
BTDP005759
Peptide Name
Alpha-conotoxin SI
Species
Conus striatus (Striated cone)
Uniprot Name
CA1_CONST
Alphafold ID
P15471
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1HJE
Sequence
MGMRMMFTVFLLVVLATTVVSFPSDRASDGRDDEAKDERSDMHESDRKEICCNPACGPKY
SCGR
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Sequence Length
64
Mass (Da)
7164
Signal Sequence
MGMRMMFTVFLLVVLATTVVS
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Sequence Removed Signal Peptide
FPSDRASDGRDDEAKDERSDMHESDRKEICCNPACGPKYSCGR
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Disulfide Bond
51-56;52-62
PDB ID
1HJE , 1QMW
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
113 nM
 . . [1- 6]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
142 nM
 . . [1- 6]
References
Ref 1 Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides. 1999;20(10):1139-44. doi: 10.1016/s0196-9781(99)00116-3.
Ref 2 The A-superfamily of conotoxins: structural and functional divergence. J Biol Chem. 2004 Apr 23;279(17):17596-606. doi: 10.1074/jbc.M309654200. Epub 2003 Dec 30.
Ref 3 Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI. Biochemistry. 1988 Sep 6;27(18):7102-5. doi: 10.1021/bi00418a065.
Ref 4 Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74. doi: 10.1021/bi970195w.
Ref 5 Cysteine-Rich -Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chem Neurosci. 2022 Apr 20;13(8):1245-1250. doi: 10.1021/acschemneuro.1c00857. Epub 2022 Mar 31.
Ref 6 Solution structure of alpha-conotoxin SI. FEBS Lett. 2000 Jul 7;476(3):287-95. doi: 10.1016/s0014-5793(00)01724-5.
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