Peptide Information

General Information of This Peptide
Peptide ID
BTDP005390
Peptide Name
Alpha-conotoxin MilIA
Species
Conus milneedwardsi (Glory of India cone snail)
Uniprot Name
CA1A_CONMD
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
DMCCHPACMNHFNC
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Sequence Length
14
Mass (Da)
1626
Sequence Removed Signal Peptide
DMCCHPACMNHFNC
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Disulfide Bond
3-8;4-14
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus milneedwardsi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-2-beta-4 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-4-beta-2 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-4-beta-4 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-7 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-9-alpha-10 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
11 μM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
13 μM
 . . [1]
References
Ref 1 Structure-Function Elucidation of a New -Conotoxin, MilIA, from Conus milneedwardsi. Mar Drugs. 2019 Sep 16;17(9):535. doi: 10.3390/md17090535.
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