Peptide Information

General Information of This Peptide
Peptide ID
BTDP004962
Peptide Name
Alpha-conotoxin TxIA
Symonym
Conotoxin tx1a
Species
Conus textile (Cloth-of-gold cone)
Uniprot Name
CA1A_CONTE
Alphafold ID
P0DM21
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2UZ6
Sequence
MFTVFLLVVLATAVVSFTSDRASDDGKAAASDLITLTIKGCCSRPPCIANNPDLCG
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Sequence Length
56
Mass (Da)
5791
Signal Sequence
MFTVFLLVVLATAVVS
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Sequence Removed Signal Peptide
FTSDRASDDGKAAASDLITLTIKGCCSRPPCIANNPDLCG
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Disulfide Bond
41-47;42-55
PDB ID
2UZ6 , 6OTA
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus textile
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-delta-epsilon Inhibition rate .
10 nM
 . [1], [2]
 Target Info    nAChR alpha-4-beta-2 Inhibition rate .
10 nM
 . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
3.5 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
392 nM
 . . [1], [2]
References
Ref 1 AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. 2007 Aug 22;26(16):3858-67. doi: 10.1038/sj.emboj.7601785. Epub 2007 Jul 26.
Ref 2 Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon. 2012 Dec 15;60(8):1370-9. doi: 10.1016/j.toxicon.2012.09.013. Epub 2012 Sep 29.
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