Peptide Information

General Information of This Peptide
Peptide ID
BTDP008641
Peptide Name
Kappa-actitoxin-Ate1a
Species
Actinia tenebrosa (Australian red waratah sea anemone)
Uniprot Name
KPHAB_ACTTE
Alphafold ID
P0DM22
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6AZA
Sequence
RCKTCSKGRCRPKPNCG
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Sequence Length
17
Mass (Da)
1894
Sequence Removed Signal Peptide
RCKTCSKGRCRPKPNCG
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Disulfide Bond
2-16;5-10
PDB ID
6AZA
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Actinia
Species: Actinia tenebrosa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv7.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
23 %
3 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
23 %
3 μM
Blocker
 [1]
 Target Info    Kv1.2 IC50
146 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
146 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
191 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
191 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
353 nM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
353 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
3.051 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
3.051 μM
 .
Blocker
 [1]
References
Ref 1 PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cell Mol Life Sci. 2018 Dec;75(24):4511-4524. doi: 10.1007/s00018-018-2897-6. Epub 2018 Aug 14.
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