Peptide Information

General Information of This Peptide
Peptide ID
BTDP008540
Peptide Name
Potassium channel toxin kappa-KTx 2.5
Symonym
OcyC8; OcyKTx6
Species
Opisthacanthus cayaporum (South American scorpion)
Uniprot Name
KKX25_OPICY
Alphafold ID
P86110
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P86110
Sequence
MESSRKSYVLMLFLAFVIMNVCSVSGEPKDGEIAGFEMEEARYDACVNACLEHHPNVREC
EEACKNPVPP
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Sequence Length
70
Mass (Da)
7823
Signal Sequence
MESSRKSYVLMLFLAFVIMNVCSVSG
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Sequence Removed Signal Peptide
EPKDGEIAGFEMEEARYDACVNACLEHHPNVRECEEACKNPVPP
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Disulfide Bond
46-64;50-60
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Hemiscorpiidae
Genus: Opisthacanthus
Species: Opisthacanthus cayaporum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Dissociation constant
71 μM
 .
Blocker
 [1]
 Target Info    Kv1.1 Dissociation constant
217 μM
 .
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Shaker Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv4.1 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Nav1.8 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
250 μM
Blocker
 [1]
 Target Info    Kv1.4 IC50
71 μM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.1 IC50
217 μM
 .
Blocker
 [1], [2], [3]
References
Ref 1 The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum. Peptides. 2011 Jul;32(7):1509-17. doi: 10.1016/j.peptides.2011.05.017. Epub 2011 May 23.
Ref 2 Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum. Toxicon. 2009 Sep 1;54(3):252-61. doi: 10.1016/j.toxicon.2009.04.010. Epub 2009 Apr 18.
Ref 3 Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum. Toxicon. 2008 Jun 15;51(8):1499-508. doi: 10.1016/j.toxicon.2008.03.029. Epub 2008 Apr 4.
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