Peptide Information

General Information of This Peptide
Peptide ID
BTDP005402
Peptide Name
Nemertide alpha-2
Species
Lineus ruber (Red bootlace) (Poseidon ruber)
Uniprot Name
NEMA2_LINRU
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
GCIATGSVCTLSKGCCTKNCGWNFKCNPPNQ
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Sequence Length
31
Mass (Da)
3236
Sequence Removed Signal Peptide
GCIATGSVCTLSKGCCTKNCGWNFKCNPPNQ
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Disulfide Bond
2-16;9-20;15-26
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Kingdom: Metazoa
Phylum: Nemertea
Class: Pilidiophora
Order: Heteronemertea
Family: Lineidae
Genus: Lineus
Species: Lineus ruber
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.1 Effective concentration 50
87.2 nM
 . . [1], [2]
 Target Info    Nav1.3 Effective concentration 50
97.9 nM
 . . [1], [2]
 Target Info    Nav1.2 Effective concentration 50
125.8 nM
 . . [1], [2]
 Target Info    Nav1.4 Effective concentration 50
127.7 nM
 . . [1], [2]
 Target Info    Nav1.6 Effective concentration 50
149.2 nM
 . . [1], [2]
 Target Info    Nav1.5 Effective concentration 50
1.1503 μM
 . . [1], [2]
 Target Info    BgNav1 Effective concentration 50
1.2967 μM
 . . [1], [2]
 Target Info    Nav1.9 Effective concentration 50
1.3618 μM
 . . [1], [2]
References
Ref 1 Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Sci Rep. 2018 Mar 22;8(1):4596. doi: 10.1038/s41598-018-22305-w.
Ref 2 Functional Characterization of the Nemertide Family of Peptide Toxins. J Nat Prod. 2021 Aug 27;84(8):2121-2128. doi: 10.1021/acs.jnatprod.1c00104. Epub 2021 Aug 16.
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