Peptide Information

General Information of This Peptide
Peptide ID
BTDP005401
Peptide Name
Nemertide alpha-1
Species
Lineus lacteus (Ribbon worm) (Ramphogordius lacteus)
Uniprot Name
NEMA1_LINLC
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
YRIASSSIAKMKTAVFLVGLLFLGLVFADEAAIDSEFDQSIDKRGCIATGSFCTLSKGCC
TKNCGWNFKCNPPNQK
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Sequence Length
76
Mass (Da)
8232
Signal Sequence
YRIASSSIAKMKTAVFLVGLLFLGLVFA
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Sequence Removed Signal Peptide
DEAAIDSEFDQSIDKRGCIATGSFCTLSKGCCTKNCGWNFKCNPPNQK
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Disulfide Bond
46-60;53-64;59-70
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Nemertea
Class: Pilidiophora
Order: Heteronemertea
Family: Lineidae
Genus: Lineus
Species: Lineus lacteus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    BgNav1 Effective concentration 50
8.6 nM
 . . [1], [2], [3]
 Target Info    Nav1.9 Effective concentration 50
76.5 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 Effective concentration 50
124.1 nM
 . . [1], [2], [3]
 Target Info    Nav1.3 Effective concentration 50
135.4 nM
 . . [1], [2], [3]
 Target Info    Nav1.5 Effective concentration 50
138.3 nM
 . . [1], [2], [3]
 Target Info    Nav1.4 Effective concentration 50
145.5 nM
 . . [1], [2], [3]
 Target Info    Nav1.6 Effective concentration 50
240.4 nM
 . . [1], [2], [3]
 Target Info    Nav1.2 Effective concentration 50
359.6 nM
 . . [1], [2], [3]
References
Ref 1 Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Sci Rep. 2018 Mar 22;8(1):4596. doi: 10.1038/s41598-018-22305-w.
Ref 2 Functional Characterization of the Nemertide Family of Peptide Toxins. J Nat Prod. 2021 Aug 27;84(8):2121-2128. doi: 10.1021/acs.jnatprod.1c00104. Epub 2021 Aug 16.
Ref 3 Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report. Front Cardiovasc Med. 2020 Jul 24;7:117. doi: 10.3389/fcvm.2020.00117. eCollection 2020.
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