Peptide Information

General Information of This Peptide
Peptide ID
BTDP008710
Peptide Name
KappaPI-actitoxin-Ael3a
Symonym
Kunitz-type serine protease inhibitor APEKTx1
Species
Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Uniprot Name
VKT1_ANTEL
Alphafold ID
P86862
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P86862
Sequence
INSICLLPKKQGFCRARFPRFYYNSSTRRCEMFYYGGCGGNANNFNTLEECEKVCLGYGE
AWKAP
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Sequence Length
65
Mass (Da)
7475
Sequence Removed Signal Peptide
INSICLLPKKQGFCRARFPRFYYNSSTRRCEMFYYGGCGGNANNFNTLEECEKVCLGYGE
AWKAP
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Disulfide Bond
5-55;14-38;30-51
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anthopleura
Species: Anthopleura elegantissima
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    trypsin Dissociation constant
124 nM
 . . [1], [2]
 Target Info    Shaker Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.2 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.4 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv2.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.6 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.5 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.3 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv4.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv11 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv4.3 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv4.2 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1 IC50
0.9 nM
 . . [1], [2]
 Target Info    Kv1 IC50
0.9 nM
 . . [1], [2]
References
Ref 1 A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem Pharmacol. 2011 Jul 1;82(1):81-90. doi: 10.1016/j.bcp.2011.03.023. Epub 2011 Apr 6.
Ref 2 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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