Peptide Information

General Information of This Peptide
Peptide ID
BTDP008592
Peptide Name
Pi-stichotoxin-Hcr5b
Symonym
APETx-like peptide; Pi-AnmTX Hcr 1b-2
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
BDS5B_HETCR
Alphafold ID
C0HL52
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HL52
Sequence
GTPCKCHGYIGVYWFMLAGCPNGYGYNLSCPYFLGICCVKK
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Sequence Length
41
Mass (Da)
4528
Sequence Removed Signal Peptide
GTPCKCHGYIGVYWFMLAGCPNGYGYNLSCPYFLGICCVKK
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Disulfide Bond
4-37;6-30;20-38
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv10 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate
5 %
1 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
10 %
1 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
10 %
1 μM
Blocker
 [1]
 Target Info    Kv7.4 Inhibition rate
10 %
1 μM
Blocker
 [1]
 Target Info    Kv7.2/7.3 Inhibition rate
10 %
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
20 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
20 %
1 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate
32 %
1 μM
Blocker
 [1]
 Target Info    KQT1 Inhibition rate
33 %
1 μM
Blocker
 [1], [2], [3]
 Target Info    Kv2.1 Inhibition rate
33 %
1 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate
36 %
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate
42 %
1 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate
47 %
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate
52 %
1 μM
Blocker
 [1]
 Target Info    acid-sensing ion channel (ASIC) IC50
4.8 μM
 . . [1], [2], [3]
 Target Info    ASIC3 IC50
15.9 μM
 . . [1], [2], [3]
References
Ref 1 A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels. Mar Drugs. 2022 Feb 17;20(2):147. doi: 10.3390/md20020147.
Ref 2 New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels. Peptides. 2018 Jun;104:41-49. doi: 10.1016/j.peptides.2018.04.013. Epub 2018 Apr 22.
Ref 3 APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels. Toxins (Basel). 2020 Apr 20;12(4):266. doi: 10.3390/toxins12040266.
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