Peptide Information

General Information of This Peptide
Peptide ID
BTDP008583
Peptide Name
Kappa-actitoxin-Bcs4a
Symonym
Potassium channel toxin BcsTx3
Species
Bunodosoma caissarum (Sea anemone)
Uniprot Name
KV53_BUNCI
Alphafold ID
C0HJC4
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJC4
Sequence
GCKGKYEECTRDSDCCDEKNRSGRKLRCLTQCDEGGCLKYRQCLFYGGLQ
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Sequence Length
50
Mass (Da)
5718
Sequence Removed Signal Peptide
GCKGKYEECTRDSDCCDEKNRSGRKLRCLTQCDEGGCLKYRQCLFYGGLQ
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Bunodosoma
Species: Bunodosoma caissarum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
54 %
3 μM
Blocker
 [1]
 Target Info    Kv1.1 IC50
˜3 nM
 .
Blocker
 [1]
 Target Info    Shaker IR potassium channel IC50
94.25 nM
 .
Blocker
 [1]
 Target Info    Shaker-IR IC50
94.25 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
172.59 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
172.59 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
1.00648 μM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
1.00668 μM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
2.24593 μM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
2.24593 μM
 .
Blocker
 [1]
References
Ref 1 BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker. FEBS J. 2013 Oct;280(19):4839-52. doi: 10.1111/febs.12456. Epub 2013 Aug 23.
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