Peptide Information

General Information of This Peptide
Peptide ID
BTDP008550
Peptide Name
Potassium channel toxin TsTXK-beta
Symonym
Potassium channel toxin beta-KTx 1; Tityustoxin K-beta; Tityustoxin-8; TsK2
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KBX1_TITSE
Alphafold ID
P69940
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P69940
Sequence
MERKLALLLILGMVTLASCGLREKHVQKLVALIPNDQLRSILKAVVHKVAKTQFGCPAYE
GYCNDHCNDIERKDGECHGFKCKCAKD
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Sequence Length
87
Mass (Da)
9729
Signal Sequence
MERKLALLLILGMVTLASC
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Sequence Removed Signal Peptide
GLREKHVQKLVALIPNDQLRSILKAVVHKVAKTQFGCPAYEGYCNDHCNDIERKDGECHG
FKCKCAKD
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Disulfide Bond
56-77;63-82;67-84
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv7.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv7.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv10 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv7.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1 IC50
30 nM
 .
Blocker
 [1- 7]
 Target Info    Kv4.2 IC50
313 nM
 .
When measured at a later moment of the depolarising test pulse (500 ms)
 [1- 7]
 Target Info    Kv4.2 IC50
652 nM
 .
When measured at the peak current
 [1- 7]
 Target Info    Kv4.2 IC50
652 nM
 .
Blocker
 [1- 7]
References
Ref 1 Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in?vivo. Toxicon. 2016 Sep 1;119:244-52. doi: 10.1016/j.toxicon.2016.06.014. Epub 2016 Jun 23.
Ref 2 Screening of expression libraries using ELISA: identification of immunogenic proteins from Tityus bahiensis and Tityus serrulatus venom. Toxicon. 2001 May;39(5):679-85. doi: 10.1016/s0041-0101(00)00194-x.
Ref 3 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 4 Evidence for a new class of scorpion toxins active against K+ channels. FEBS Lett. 1998 Jul 24;431(3):375-80. doi: 10.1016/s0014-5793(98)00780-7.
Ref 5 Tityus serrulatus venom peptidomics: assessing venom peptide diversity. Toxicon. 2008 Oct;52(5):611-8. doi: 10.1016/j.toxicon.2008.07.010. Epub 2008 Jul 31.
Ref 6 Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes. Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1475-9. doi: 10.1073/pnas.91.4.1475.
Ref 7 Tityus serrulatus scorpion venom and toxins: an overview. Protein Pept Lett. 2009;16(8):920-32. doi: 10.2174/092986609788923329.
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