Peptide Information

General Information of This Peptide
Peptide ID
BTDP008522
Peptide Name
Potassium channel toxin alpha-KTx 8.8
Symonym
OSK3
Species
Orthochirus scrobiculosus (Central Asian scorpion)
Uniprot Name
KAX88_ORTSC
Alphafold ID
A0A1L2FZD4
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: A0A1L2FZD4
Sequence
MCRLYAIILIVLVMNVIMTIIPDSKVEVVSCEDCPEHCSTQKARAKCDNDKCVCEPI
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Sequence Length
57
Mass (Da)
6386
Sequence Removed Signal Peptide
MCRLYAIILIVLVMNVIMTIIPDSKVEVVSCEDCPEHCSTQKARAKCDNDKCVCEPI
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Disulfide Bond
31-47;34-52;38-54
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Orthochirus
Species: Orthochirus scrobiculosus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-IR Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 IC50
331 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
331 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
503 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
503 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
9.983 μM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
9.983 μM
 .
Blocker
 [1]
References
Ref 1 C-Terminal residues in small potassium channel blockers OdK1 and OSK3 from scorpion venom fine-tune the selectivity. Biochim Biophys Acta Proteins Proteom. 2017 May;1865(5):465-472. doi: 10.1016/j.bbapap.2017.02.001. Epub 2017 Feb 4.
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