Peptide Information

General Information of This Peptide
Peptide ID
BTDP008375
Peptide Name
Kappa-actitoxin-Bcs3a
Symonym
Potassium channel toxin BcsTx1
Species
Bunodosoma caissarum (Sea anemone)
Uniprot Name
K1B1_BUNCI
Alphafold ID
C0HJC2
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJC2
Sequence
ACIDRFPTGTCKHVKKGGSCKNSQKYRINCAKTCGLCH
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Sequence Length
38
Mass (Da)
4158
Sequence Removed Signal Peptide
ACIDRFPTGTCKHVKKGGSCKNSQKYRINCAKTCGLCH
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Disulfide Bond
2-37;11-30;20-34
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Bunodosoma
Species: Bunodosoma caissarum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv4.1 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
500 nM
Blocker
 [1]
 Target Info    Kv1.2 IC50
0.03 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
0.03 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
1.31 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
1.31 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
74 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
74.11 nM
 .
Blocker
 [1]
 Target Info    Shaker-IR IC50
247.69 nM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
405 nM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
405 nM
 .
Blocker
 [1]
References
Ref 1 Biochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar Drugs. 2013 Mar 6;11(3):655-79. doi: 10.3390/md11030655.
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