Peptide Information

General Information of This Peptide
Peptide ID
BTDP008363
Peptide Name
Crotamine
Symonym
Myotoxin
Species
Crotalus durissus terrificus (South American rattlesnake)
Uniprot Name
MYC2_CRODU
Alphafold ID
Q9PWF3
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1H5O
Sequence
MKILYLLFAFLFLAFLSEPGNAYKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCK
KGSGK
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Sequence Length
65
Mass (Da)
7519
Signal Sequence
MKILYLLFAFLFLAFLSEPGNA
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Sequence Removed Signal Peptide
YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSGK
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Disulfide Bond
26-58;33-52;40-59
PDB ID
1H5O , 1Z99
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Crotalus
Species: Crotalus durissus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-IR Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv4.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
287 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
287 nM
 .
Blocker
 [1- 18]
 Target Info    Kv1.1 IC50
369 nM
 .
Blocker
 [1- 18]
 Target Info    Kv1 IC50
369 nM
 .
Blocker
 [1- 18]
 Target Info    Kv1.2 IC50
386 nM
 .
Blocker
 [1- 18]
 Target Info    Kv1.2 IC50
386 nM
 .
Blocker
 [1- 18]
References
Ref 1 Crotamine pharmacology revisited: novel insights based on the inhibition of KV channels. Mol Pharmacol. 2012 Jul;82(1):90-6. doi: 10.1124/mol.112.078188. Epub 2012 Apr 12.
Ref 2 Nucleotide sequence of crotamine isoform precursors from a single South American rattlesnake (Crotalus durissus terrificus). Toxicon. 1999 Jul;37(7):973-84. doi: 10.1016/s0041-0101(98)00226-8.
Ref 3 Structure and chromosomal localization of the gene for crotamine, a toxin from the South American rattlesnake, Crotalus durissus terrificus. Toxicon. 2003 Dec;42(7):747-52. doi: 10.1016/j.toxicon.2003.10.019.
Ref 4 [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5.
Ref 5 Effect of crotamine, a toxin of South American rattlesnake venom, on the sodium channel of murine skeletal muscle. Br J Pharmacol. 1978 Jul;63(3):551-9. doi: 10.1111/j.1476-5381.1978.tb07811.x.
Ref 6 The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. doi: 10.1016/s0041-0101(98)00117-2.
Ref 7 Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus. FASEB J. 2004 Sep;18(12):1407-9. doi: 10.1096/fj.03-1459fje. Epub 2004 Jul 1.
Ref 8 Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans. J Biol Chem. 2007 Jul 20;282(29):21349-60. doi: 10.1074/jbc.M604876200. Epub 2007 May 9.
Ref 9 Crotamine inhibits preferentially fast-twitching muscles but is inactive on sodium channels. Toxicon. 2007 Sep 15;50(4):553-62. doi: 10.1016/j.toxicon.2007.04.026. Epub 2007 May 18.
Ref 10 Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization. Toxicon. 2008 Sep 1;52(3):508-17. doi: 10.1016/j.toxicon.2008.06.029. Epub 2008 Jul 10.
Ref 11 Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. doi: 10.1073/pnas.0904465106. Epub 2009 Aug 13.
Ref 12 Crotamine toxicity and efficacy in mouse models of melanoma. Expert Opin Investig Drugs. 2011 Sep;20(9):1189-200. doi: 10.1517/13543784.2011.602064.
Ref 13 In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus. J Antibiot (Tokyo). 2011 Apr;64(4):327-31. doi: 10.1038/ja.2011.10. Epub 2011 Mar 9.
Ref 14 The natural cell-penetrating peptide crotamine targets tumor tissue in vivo and triggers a lethal calcium-dependent pathway in cultured cells. Mol Pharm. 2012 Feb 6;9(2):211-21. doi: 10.1021/mp2000605. Epub 2011 Dec 23.
Ref 15 Unraveling the antifungal activity of a South American rattlesnake toxin crotamine. Biochimie. 2013 Feb;95(2):231-40. doi: 10.1016/j.biochi.2012.09.019. Epub 2012 Sep 26.
Ref 16 Biological versatility of crotamine--a cationic peptide from the venom of a South American rattlesnake. Expert Opin Investig Drugs. 2010 Dec;19(12):1515-25. doi: 10.1517/13543784.2010.534457. Epub 2010 Nov 10.
Ref 17 Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem. 2003 May;270(9):1969-79. doi: 10.1046/j.1432-1033.2003.03563.x.
Ref 18 Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus. Toxicon. 2005 Dec 1;46(7):759-67. doi: 10.1016/j.toxicon.2005.07.018. Epub 2005 Sep 26.
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