Peptide Information

General Information of This Peptide
Peptide ID
BTDP008751
Peptide Name
Bgk (W5Y,Y26F)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VCRDWFKETACRHAKSLGNCRTSQKYRANCAKTLQCC
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Mutant Sequence
VCRDYFKETACRHAKSLGNCRTSQKFRANCAKTLQCC
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Sequence Length
37
Mass(Da)
4237
Sequence Removed Signal Peptide
VCRDYFKETACRHAKSLGNCRTSQKFRANCAKTCELC
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Disulfide Bond
2-30;11-36;20-37
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.6 Dissociation constant
4 pM
 .
Blocker
 [1]
 Target Info    Kv1 Dissociation constant
5 pM
 .
Blocker
 [1]
 Target Info    Kv1.2-1.1 Dissociation constant
9 pM
 .
Blocker
 [1]
 Target Info    Kv1.1 Dissociation constant
0.035 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
0.077 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 Inhibition constant
0.014 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 Inhibition constant
0.104 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 Inhibition constant
0.369 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition constant
1.809 nM
 .
Blocker
 [1]
References
Ref 1 Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain. J Biol Chem. 2002 Feb 8;277(6):3886-93. doi: 10.1074/jbc.M109886200. Epub 2001 Nov 13.
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