Peptide Information

General Information of This Peptide
Peptide ID
BTDP008672
Peptide Name
Potassium channel toxin alpha-KTx 12.1
Symonym
Butantoxin; Tityustoxin-6; TsTX-IV
Species
Tityus serrulatus (Brazilian scorpion)
Uniprot Name
KA121_TITSE
Alphafold ID
P59936
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1C55
Sequence
MQVFYGLLLMFILCSTIHLSEQWCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRC
YT
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Sequence Length
62
Mass (Da)
7083
Signal Sequence
MQVFYGLLLMFILCSTIHLSEQ
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Sequence Removed Signal Peptide
WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
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Disulfide Bond
24-27;32-53;38-58;42-60
PDB ID
1C55 , 1C56 , 1WT7
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus serrulatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate
5 %
1 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
9 %
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate
11 %
1 μM
Blocker
 [1]
 Target Info    Kv7.2 Inhibition rate
14 %
1 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate
20 %
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate
25 %
1 μM
Blocker
 [1]
 Target Info    Shaker Inhibition rate
80 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.55 nM
 .
Blocker
 [1- 11]
 Target Info    Kv1.3 IC50
0.55 nM
 .
Blocker
 [1- 11]
 Target Info    Kv1.2 IC50
6.19 nM
 .
Blocker
 [1- 11]
 Target Info    Kv1.2 IC50
6.19 nM
 .
Blocker
 [1- 11]
 Target Info    KCa3.1 IC50
12.3 nM
 .
Blocker
 [11]
 Target Info    Kv1 IC50
46 nM
 .
Blocker
 [1- 11]
 Target Info    Kv1.2 IC50
165 nM
 .
Blocker
 [1- 11]
References
Ref 1 Electrophysiological characterization of Ts6 and Ts7, K? channel toxins isolated through an improved Tityus serrulatus venom purification procedure. Toxins (Basel). 2014 Feb 28;6(3):892-913. doi: 10.3390/toxins6030892.
Ref 2 Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. PLoS One. 2018 Mar 21;13(3):e0193739. doi: 10.1371/journal.pone.0193739. eCollection 2018.
Ref 3 Novel components of Tityus serrulatus venom: A transcriptomic approach. Toxicon. 2021 Jan 15;189:91-104. doi: 10.1016/j.toxicon.2020.11.001. Epub 2020 Nov 10.
Ref 4 TsTX-IV, a short chain four-disulfide-bridged neurotoxin from Tityus serrulatus venom which acts on Ca2+-activated K+ channels. Toxicon. 1999 Apr;37(4):651-60. doi: 10.1016/s0041-0101(98)00206-2.
Ref 5 NMR solution structure of butantoxin. Arch Biochem Biophys. 2000 Jul 1;379(1):18-27. doi: 10.1006/abbi.2000.1858.
Ref 6 Covalent structure and some pharmacological features of native and cleaved alpha-KTx12-1, a four disulfide-bridged toxin from Tityus serrulatus venom. J Pept Sci. 2003 Feb;9(2):132-40. doi: 10.1002/psc.440.
Ref 7 Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity. Toxicon. 2014 Nov;90:326-36. doi: 10.1016/j.toxicon.2014.08.064. Epub 2014 Sep 6.
Ref 8 Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators. Toxicon. 2011 Jun;57(7-8):1101-8. doi: 10.1016/j.toxicon.2011.04.017. Epub 2011 Apr 29.
Ref 9 Ts6 and Ts2 from Tityus serrulatus venom induce inflammation by mechanisms dependent on lipid mediators and cytokine production. Toxicon. 2013 Jan;61:1-10. doi: 10.1016/j.toxicon.2012.10.002. Epub 2012 Oct 22.
Ref 10 Probing the pH-dependent structural features of alpha-KTx12.1, a potassium channel blocker from the scorpion Tityus serrulatus. Protein Sci. 2005 Apr;14(4):1025-38. doi: 10.1110/ps.041131205.
Ref 11 Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity. Proteins. 2005 Aug 15;60(3):401-11. doi: 10.1002/prot.20509.
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