Peptide Information

General Information of This Peptide
Peptide ID
BTDP008520
Peptide Name
Potassium channel toxin alpha-KTx 8.6
Symonym
MeuTXKalpha1; Toxin MeuKTx-1; meuK-toxin; pMeKTx1-1
Species
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Uniprot Name
KAX86_MESEU
Alphafold ID
P86400
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P86400
Sequence
MSRLYAIILIALVFNVIMTIMPDMKVEAVSCEDCPEHCATKDQRAKCDNDKCVCEPK
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Sequence Length
57
Mass (Da)
6435
Sequence Removed Signal Peptide
MSRLYAIILIALVFNVIMTIMPDMKVEAVSCEDCPEHCATKDQRAKCDNDKCVCEPK
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Disulfide Bond
31-47;34-52;38-54
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus eupeus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1], [2]
 Target Info    Kv1.2 Inhibition rate .
3 μM
Blocker
 [1], [2]
 Target Info    Kv1 Inhibition rate .
3 μM
Blocker
 [1], [2]
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
3 μM
Blocker
 [1], [2]
 Target Info    Kv1.6 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1], [2]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1], [2]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
35 %
3 μM
Blocker
 [1], [2]
 Target Info    Kv1 Inhibition rate
35 %
3 μM
Blocker
 [1]
 Target Info    Shaker-IR Inhibition rate
70 %
3 μM
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
2.36 nM
 .
Blocker
 [1]
 Target Info    Shaker IC50
3 μM
 .
Blocker
 [1]
References
Ref 1 Molecular diversity and functional evolution of scorpion potassium channel toxins. Mol Cell Proteomics. 2011 Feb;10(2):M110.002832. doi: 10.1074/mcp.M110.002832. Epub 2010 Sep 30.
Ref 2 Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY. J Biol Chem. 2015 May 8;290(19):12195-209. doi: 10.1074/jbc.M115.637611. Epub 2015 Mar 19.
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