Peptide Information

General Information of This Peptide
Peptide ID
BTDP008446
Peptide Name
Potassium channel toxin alpha-KTx 1.15
Symonym
BmKcug2
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KAX1F_MESMA
Alphafold ID
H2ER23
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: H2ER23
Sequence
MKISFLLLALVICSIGWSEAQFTDVKCTASKQCWPVCNQMFGKPNGKCMNGKCRCYS
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Sequence Length
57
Mass (Da)
6370
Signal Sequence
MKISFLLLALVICSIGWSEA
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Sequence Removed Signal Peptide
QFTDVKCTASKQCWPVCNQMFGKPNGKCMNGKCRCYS
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Disulfide Bond
27-48;33-53;37-55
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv11 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv4.3 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv4.2 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv3.2 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv1.1 Inhibition rate
4 %
1 μM
Blocker
 [2]
 Target Info    Kv1.6 Inhibition rate
5 %
1 μM
Blocker
 [2]
 Target Info    Kv1.2 IC50
46 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
215.3 nM
 .
Blocker
 [2]
References
Ref 1 Identification and molecular characterization of three new K+-channel specific toxins from the Chinese scorpion Mesobuthus martensii Karsch revealing intronic number polymorphism and alternative splicing in duplicated genes. Peptides. 2012 Apr;34(2):311-23. doi: 10.1016/j.peptides.2011.12.012. Epub 2012 Jan 3.
Ref 2 Different pharmacological properties between scorpion toxin BmKcug2 and its degraded analogs highlight the diversity of K(+) channel blockers from thermally processed scorpions. Int J Biol Macromol. 2021 May 1;178:143-153. doi: 10.1016/j.ijbiomac.2021.02.155. Epub 2021 Feb 23.
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