Peptide Information

General Information of This Peptide
Peptide ID
BTDP008407
Peptide Name
Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin
Symonym
Protease inhibitor 1 homolog; Toxin C13S2C3; Venom basic protease inhibitor 1 homolog
Species
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Uniprot Name
VKTHA_DENAN
Alphafold ID
P00980
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1DTX
Sequence
QPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG
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Sequence Length
59
Mass (Da)
7071
Sequence Removed Signal Peptide
QPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG
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Disulfide Bond
7-57;16-40;32-53
PDB ID
1DTX
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis angusticeps
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1-1.2 Dissociation constant
0.34 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1-1.2 Dissociation constant
0.5 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Dissociation constant
0.6 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Dissociation constant
0.74 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1 Dissociation constant
1.1 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Dissociation constant
1.7 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1 Dissociation constant
2.8 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Inhibition constant
0.6 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1 Inhibition constant
4 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 Inhibition rate .
100 nM
Blocker
 [5]
 Target Info    Kv1.4 Inhibition rate .
200 nM
Blocker
 [6]
 Target Info    Kv1.5 Inhibition rate .
200 nM
Blocker
 [7]
 Target Info    Kv3.2 Inhibition rate .
100 nM
Blocker
 [8]
 Target Info    Kv4.1 Inhibition rate .
100 nM
Blocker
 [8]
 Target Info    Kir1.1 Inhibition rate .
150 nM
Blocker
 [9]
 Target Info    Kv3.4 Inhibition rate .
100 nM
Blocker
 [8]
 Target Info    Kv4.2 Inhibition rate .
300 nM
Blocker
 [10]
 Target Info    Kv1.2 Effective concentration 50
0.38 nM
 .
Blocker
 [5]
 Target Info    Kv1.1 Effective concentration 50
9.4 nM
 .
Blocker
 [11]
 Target Info    Kv1.1 IC50
0.4 - 150 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 IC50
0.4 - 150 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.6 IC50
0.4 - 150 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.6-1.2 IC50
5.7 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1-1.2 IC50
8 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.6 IC50
9 nM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Snake venoms. The amino acid sequences of two proteinase inhibitor homologues from Dendroaspis angusticeps venom. Hoppe Seylers Z Physiol Chem. 1980 May;361(5):661-74. doi: 10.1515/bchm2.1980.361.1.661.
Ref 2 Twenty years of dendrotoxins. Toxicon. 2001 Jan;39(1):15-26. doi: 10.1016/s0041-0101(00)00162-8.
Ref 3 Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals. Mar Drugs. 2013 Jun 14;11(6):2069-112. doi: 10.3390/md11062069.
Ref 4 Crystal structure of alpha-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor. J Mol Biol. 1992 Apr 5;224(3):671-83. doi: 10.1016/0022-2836(92)90552-u.
Ref 5 Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels. Mol Pharmacol. 1991 Oct;40(4):572-6.
Ref 6 Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J. 1989 Nov;8(11):3235-44. doi: 10.1002/j.1460-2075.1989.tb08483.x.
Ref 7 Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron. 1990 Jun;4(6):929-39. doi: 10.1016/0896-6273(90)90146-7.
Ref 8 Characterization of a Shaw-related potassium channel family in rat brain. EMBO J. 1992 Jul;11(7):2473-86. doi: 10.1002/j.1460-2075.1992.tb05312.x.
Ref 9 A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry. 1998 Oct 20;37(42):14867-74. doi: 10.1021/bi980929k.
Ref 10 Functional characterization of RK5, a voltage-gated K+ channel cloned from the rat cardiovascular system. FEBS Lett. 1991 Dec 16;295(1-3):211-3. doi: 10.1016/0014-5793(91)81420-d.
Ref 11 The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Mar;120(6):1029-34. doi: 10.1038/sj.bjp.0701004.
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