Peptide Information

General Information of This Peptide
Peptide ID
BTDP008381
Peptide Name
Kappa-conotoxin RIIIK
Symonym
Conotoxin R3.1
Species
Conus radiatus (Rayed cone)
Uniprot Name
CM3K_CONRA
Alphafold ID
P69769
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P69769
Sequence
MSKLGVLLTICLLLFPLTALPMDGDQPVDRLAERMQDNISSEQHTFFEKRLPSCCSLNLR
LCPVPACKRNPCCTG
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Sequence Length
75
Mass (Da)
8351
Signal Sequence
MSKLGVLLTICLLLFPLTA
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Sequence Removed Signal Peptide
LPMDGDQPVDRLAERMQDNISSEQHTFFEKRLPSCCSLNLRLCPVPACKRNPCCTG
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Disulfide Bond
54-67;55-72;62-73
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus radiatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    Kv1.6 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    Kv1.5 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    KCa1.1 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    Kv7.2/7.3 Inhibition rate .
100 μM
Blocker
 [3]
 Target Info    Kv1.2 IC50
352 nM
 .
Blocker
 [3]
 Target Info    Kv1.7-1.2 IC50
680 nM
 .
Blocker
 [3]
 Target Info    Kv1.5-1.2 IC50
2.76 μM
 .
Blocker
 [3]
 Target Info    Kv1.2-1.1 IC50
2.8 μM
 .
Blocker
 [3]
 Target Info    Kv1.6-1.2 IC50
7.74 μM
 .
Blocker
 [3]
References
Ref 1 Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry. 2005 Jun 7;44(22):8176-86. doi: 10.1021/bi047541b.
Ref 2 A novel conus peptide ligand for K+ channels. J Biol Chem. 2003 Jan 24;278(4):2177-83. doi: 10.1074/jbc.M205953200. Epub 2002 Oct 23.
Ref 3 Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem. 2010 May 14;285(20):14882-14889. doi: 10.1074/jbc.M109.068486. Epub 2010 Mar 10.
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