Peptide Information

General Information of This Peptide
Peptide ID
BTDP008380
Peptide Name
Kappa-conotoxin RIIIJ
Symonym
Kappa-M-RIIIJ
Species
Conus radiatus (Rayed cone)
Uniprot Name
CM3J_CONRA
Alphafold ID
P0CG45
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0CG45
Sequence
LPPCCTPPKKHCPAPACKYKPCCKS
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Sequence Length
25
Mass (Da)
2807
Sequence Removed Signal Peptide
LPPCCTPPKKHCPAPACKYKPCCKS
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Disulfide Bond
4-17;5-22;12-23
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus radiatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
70 μM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
70 μM
Blocker
 [1]
 Target Info    Kv7.2/7.3 Inhibition rate .
70 μM
Blocker
 [1]
 Target Info    Kv1.6-1.2 IC50
0.5 nM
 .
Blocker
 [2]
 Target Info    Kv1.2-1.1 IC50
1.2 nM
 .
Blocker
 [2]
 Target Info    Kv1.6-1.2 IC50
6.1 nM
 .
Blocker
 [2]
 Target Info    Kv1.6-1.2 IC50
8.7 nM
 .
Blocker
 [2]
 Target Info    Kv1.2-1.1 IC50
12 nM
 .
Blocker
 [1]
 Target Info    Kv1.6-1.2 IC50
13.6 nM
 .
Blocker
 [2]
 Target Info    Kv1.2-1.1 IC50
14.3 nM
 .
Blocker
 [2]
 Target Info    Kv1.6-1.2 IC50
15.9 nM
 .
Blocker
 [2]
 Target Info    Kv1.2-1.1 IC50
18.4 nM
 .
Blocker
 [2]
 Target Info    Kv1.6-1.2 IC50
24 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
33 nM
 .
Blocker
 [1]
 Target Info    Kv1.5-1.2 IC50
47 nM
 .
Blocker
 [1]
 Target Info    Kv1.6-1.2 IC50
64.6 nM
 .
Blocker
 [2]
 Target Info    Kv1.2 IC50
98.3 nM
 .
Blocker
 [2]
 Target Info    Kv1.5-1.2 IC50
99 nM
 .
Blocker
 [2]
 Target Info    Kv1.3-1.2 IC50
138 nM
 .
Blocker
 [2]
 Target Info    Kv1.3-1.2 IC50
165 nM
 .
Blocker
 [2]
 Target Info    Kv1.7-1.2 IC50
267 nM
 .
Blocker
 [2]
 Target Info    Kv1.5-1.2 IC50
287 nM
 .
Blocker
 [2]
 Target Info    Kv1.7-1.2 IC50
370 nM
 .
Blocker
 [2]
 Target Info    Kv1.4-1.2 IC50
747 nM
 .
Blocker
 [2]
 Target Info    Kv1.4-1.2 IC50
1.64 μM
 .
Blocker
 [2]
 Target Info    Kv1.7-1.2 IC50
3.15 μM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
4 μM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
8 μM
 .
Blocker
 [1]
 Target Info    Kv1.4-1.2 IC50
8.13 μM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
10 μM
 .
Blocker
 [1]
 Target Info    Kv1.5 IC50
70 μM
 .
Blocker
 [1]
References
Ref 1 Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem. 2010 May 14;285(20):14882-14889. doi: 10.1074/jbc.M109.068486. Epub 2010 Mar 10.
Ref 2 Conotoxin M-RIIIJ, a tool targeting asymmetric heteromeric K(v)1 channels. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):1059-1064. doi: 10.1073/pnas.1813161116. Epub 2018 Dec 28.
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