Peptide Information

General Information of This Peptide
Peptide ID
BTDP003657
Peptide Name
Mu-conotoxin CnIIIC
Species
Conus consors (Singed cone)
Uniprot Name
GM3C_CONCN
Alphafold ID
I1SB07
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2YEN
Sequence
QGCCNGPKGCSSKWCRDHARCC
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Sequence Length
22
Mass (Da)
2400
Sequence Removed Signal Peptide
QGCCNGPKGCSSKWCRDHARCC
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Disulfide Bond
3-15;4-21;10-22
PDB ID
2YEN
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus consors
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.6 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.5 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv11/ERG Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Shaker-IR Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Nav1.8 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Nav1.5 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Nav1.4 IC50
1.3 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-3/beta-2 IC50
450 nM
 . . [1], [2], [3]
References
Ref 1 A novel -conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Br J Pharmacol. 2012 Jul;166(5):1654-68. doi: 10.1111/j.1476-5381.2012.01837.x.
Ref 2 Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics. 2012 Sep 18;75(17):5215-25. doi: 10.1016/j.jprot.2012.06.001. Epub 2012 Jun 13.
Ref 3 Peptide therapeutics from venom: Current status and potential. Bioorg Med Chem. 2018 Jun 1;26(10):2738-2758. doi: 10.1016/j.bmc.2017.09.029. Epub 2017 Sep 23.
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