Target Information

General Information of This Target
Target ID
BTDT10171
Target Name
Nicotinic acetylcholine receptor
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Long neurotoxin Tx-NM3-1 Inhibition constant
1.66 nM
 [1]
 Toxin Info    Long neurotoxin Tx-NM2 Inhibition constant
8.66 nM
 [1]
 Toxin Info    Conotoxin AusB Effect . [2]
 Toxin Info    Conotoxin phi-MiXXVIIB Effect . [3]
 Toxin Info    Kappa-bungarotoxin IC50
<100 nM
 [4- 11]
 Toxin Info    Kappa-flavitoxin IC50
<100 nM
 [12], [13], [14]
 Toxin Info    Kappa-2-bungarotoxin IC50
<100 nM
 [15], [16]
 Toxin Info    Kappa-3-bungarotoxin IC50
<100 nM
 [5- 16]
References
Ref 1 Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABA(A) and Nicotinic Acetylcholine Receptors. Toxins (Basel). 2021 Feb 20;13(2):164. doi: 10.3390/toxins13020164.
Ref 2 Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs. 2016 Oct 27;14(11):199. doi: 10.3390/md14110199.
Ref 3 Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol Cell Proteomics. 2013 Dec;12(12):3824-33. doi: 10.1074/mcp.M113.030353. Epub 2013 Sep 16.
Ref 4 cDNA sequence analysis and expression of kappa-bungarotoxin from Taiwan banded krait. Biochem Biophys Res Commun. 1997 Jan 3;230(1):192-5. doi: 10.1006/bbrc.1996.5916.
Ref 5 Organization and phylogenetic analysis of kappa-bungarotoxin genes from Bungarus multicinctus (Taiwan banded krait). Genetica. 2002 Jun;115(2):213-21. doi: 10.1023/a:1020139728292.
Ref 6 kappa-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe. Biochemistry. 1985 Mar 12;24(6):1532-7. doi: 10.1021/bi00327a036.
Ref 7 Amino acid sequence of toxin F, a snake venom toxin that blocks neuronal nicotinic receptors. Brain Res. 1986 Oct 15;385(1):30-7. doi: 10.1016/0006-8993(86)91543-x.
Ref 8 Binding of native kappa-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors. Toxicon. 1996 Nov-Dec;34(11-12):1243-56. doi: 10.1016/s0041-0101(96)00110-9.
Ref 9 Crystal structure of kappa-bungarotoxin at 2.3-A resolution. Biochemistry. 1994 Nov 8;33(44):13147-54. doi: 10.1021/bi00248a026.
Ref 10 Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: sequence-specific assignments, secondary structure, and dimer formation. Biochemistry. 1991 May 21;30(20):4901-9. doi: 10.1021/bi00234a010.
Ref 11 Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. Biochemistry. 1992 Mar 24;31(11):2962-70. doi: 10.1021/bi00126a017.
Ref 12 Amino acid sequence of kappa-flavitoxin: establishment of a new family of snake venom neurotoxins. Biochemistry. 1988 May 17;27(10):3794-8. doi: 10.1021/bi00410a041.
Ref 13 Kappa-flavitoxin: isolation of a new neuronal nicotinic receptor antagonist that is structurally related to kappa-bungarotoxin. Brain Res. 1987 Jan 27;402(1):21-9. doi: 10.1016/0006-8993(87)91043-2.
Ref 14 Homologous kappa-neurotoxins exhibit residue-specific interactions with the alpha 3 subunit of the nicotinic acetylcholine receptor: a comparison of the structural requirements for kappa-bungarotoxin and kappa-flavitoxin binding. Biochemistry. 1993 Jul 13;32(27):6988-94. doi: 10.1021/bi00078a025.
Ref 15 cDNA deduced amino-acid sequences of two novel kappa-neurotoxins from Bungarus multicinctus. Nucleic Acids Res. 1990 Feb 25;18(4):1050. doi: 10.1093/nar/18.4.1050.
Ref 16 Kappa 2-bungarotoxin and kappa 3-bungarotoxin: two new neuronal nicotinic receptor antagonists isolated from the venom of Bungarus multicinctus. Brain Res. 1990 Feb 19;509(2):237-48. doi: 10.1016/0006-8993(90)90548-p.
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