Peptide Information

General Information of This Peptide
Peptide ID
BTDP005386
Peptide Name
Long neurotoxin Tx-NM3-1
Species
Naja melanoleuca (Forest cobra) (Black-lipped cobra)
Uniprot Name
3L24_NAJME
Alphafold ID
P0DQQ2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQQ2
Sequence
IRCFITPDVTSQICADGHVCYTKTWCDAWCTSRGKRVDLGCAATCPTVKTGVDIKCCSTD
NCNPFPTRNRP
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Sequence Length
71
Mass (Da)
7803
Sequence Removed Signal Peptide
IRCFITPDVTSQICADGHVCYTKTWCDAWCTSRGKRVDLGCAATCPTVKTGVDIKCCSTD
NCNPFPTRNRP
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Disulfide Bond
3-20;14-41;26-30;45-56;57-62
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja melanoleuca
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Inhibition constant
1.66 nM
 .
Competitive binding with alpha-bungarotoxin
 [1]
 Target Info    nAChR alpha-7 Inhibition constant
4.84 nM
 .
Competitive binding with alpha-bungarotoxin
 [1]
 Target Info    GABA(A) alpha-1-beta-3-gamma-2 receptor IC50
0.68 μM
 .
Competitive binding with alpha-bungarotoxin
 [1]
References
Ref 1 Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABA(A) and Nicotinic Acetylcholine Receptors. Toxins (Basel). 2021 Feb 20;13(2):164. doi: 10.3390/toxins13020164.
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