Peptide Information

General Information of This Peptide
Peptide ID
BTDP005385
Peptide Name
Long neurotoxin Tx-NM2
Species
Naja melanoleuca (Forest cobra) (Black-lipped cobra)
Uniprot Name
3L23_NAJME
Alphafold ID
P0DQQ1
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DQQ1
Sequence
KRCYRTPDLKSQTCPPGEDLCYTKKWCADWCTSRGKVIELGCVATCPTVKPYEEITCCST
DNCNPHPKMPKP
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Sequence Length
72
Mass (Da)
8127
Sequence Removed Signal Peptide
KRCYRTPDLKSQTCPPGEDLCYTKKWCADWCTSRGKVIELGCVATCPTVKPYEEITCCST
DNCNPHPKMPKP
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Disulfide Bond
3-21;14-42;27-31;46-57;58-63
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja melanoleuca
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Inhibition constant
8.66 nM
 .
Competitive binding with alpha-bungarotoxin
 [1]
 Target Info    nAChR alpha-7 Inhibition constant
9.47 nM
 .
Competitive binding with alpha-bungarotoxin
 [1]
 Target Info    GABA(A) alpha-1-beta-3-gamma-2 receptor IC50
1.25 μM
 .
Competitive binding with alpha-bungarotoxin
 [1]
References
Ref 1 Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABA(A) and Nicotinic Acetylcholine Receptors. Toxins (Basel). 2021 Feb 20;13(2):164. doi: 10.3390/toxins13020164.
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