Peptide Information

General Information of This Peptide
Peptide ID
BTDP003876
Peptide Name
Kappa-bungarotoxin
Symonym
Kappa-1-bungarotoxin; Long neurotoxin 2; Neuronal bungarotoxin; Toxin F
Species
Bungarus multicinctus (Many-banded krait)
Uniprot Name
3LKB_BUNMU
Alphafold ID
P01398
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1KBA
Sequence
MKTLLLTLVVVTIVCLDLGYTRTCLISPSSTPQTCPNGQDICFLKAQCDKFCSIRGPVIE
QGCVATCPQFRSNYRSLLCCTTDNCNH
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Sequence Length
87
Mass (Da)
9566
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
RTCLISPSSTPQTCPNGQDICFLKAQCDKFCSIRGPVIEQGCVATCPQFRSNYRSLLCCT
TDNCNH
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Disulfide Bond
24-42;35-63;48-52;67-79;80-85
PDB ID
1KBA , 2NBT , 7ULR
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Bungarus
Species: Bungarus multicinctus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR IC50
<100 nM
 . . [1- 8]
References
Ref 1 cDNA sequence analysis and expression of kappa-bungarotoxin from Taiwan banded krait. Biochem Biophys Res Commun. 1997 Jan 3;230(1):192-5. doi: 10.1006/bbrc.1996.5916.
Ref 2 Organization and phylogenetic analysis of kappa-bungarotoxin genes from Bungarus multicinctus (Taiwan banded krait). Genetica. 2002 Jun;115(2):213-21. doi: 10.1023/a:1020139728292.
Ref 3 kappa-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe. Biochemistry. 1985 Mar 12;24(6):1532-7. doi: 10.1021/bi00327a036.
Ref 4 Amino acid sequence of toxin F, a snake venom toxin that blocks neuronal nicotinic receptors. Brain Res. 1986 Oct 15;385(1):30-7. doi: 10.1016/0006-8993(86)91543-x.
Ref 5 Binding of native kappa-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors. Toxicon. 1996 Nov-Dec;34(11-12):1243-56. doi: 10.1016/s0041-0101(96)00110-9.
Ref 6 Crystal structure of kappa-bungarotoxin at 2.3-A resolution. Biochemistry. 1994 Nov 8;33(44):13147-54. doi: 10.1021/bi00248a026.
Ref 7 Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: sequence-specific assignments, secondary structure, and dimer formation. Biochemistry. 1991 May 21;30(20):4901-9. doi: 10.1021/bi00234a010.
Ref 8 Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. Biochemistry. 1992 Mar 24;31(11):2962-70. doi: 10.1021/bi00126a017.
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