Target Information

General Information of This Target
Target ID
BTDT10160
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-9-alpha-10
Target Bioclass
Receptor
Taxonomy ID
9606
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Elevenin Effect . [1]
 Toxin Info    Elevenin Effect . [2]
 Toxin Info    Alpha-conotoxin GeXXA IC50
28 nM
 [3], [4]
 Toxin Info    Alpha-conotoxin Mr1.1 IC50
92 nM
 [5], [6], [7]
 Toxin Info    Alpha-conotoxin G1.5 IC50
569 nM
 [8], [9]
 Toxin Info    Turripeptide ubi3a IC50
10.2 μM
 [10]
References
Ref 1 A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae). Toxins (Basel). 2021 Sep 10;13(9):642. doi: 10.3390/toxins13090642.
Ref 2 Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus. Mar Drugs. 2022 Feb 17;20(2):149. doi: 10.3390/md20020149.
Ref 3 Conotoxin D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep. 2015 Sep 23;5:14261. doi: 10.1038/srep14261.
Ref 4 High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. Mar Drugs. 2019 Mar 26;17(3):193. doi: 10.3390/md17030193.
Ref 5 From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon. 2007 Jun 15;49(8):1135-49. doi: 10.1016/j.toxicon.2007.02.011. Epub 2007 Mar 1.
Ref 6 Chemical synthesis and characterization of two 4/7-conotoxins. Acta Biochim Biophys Sin (Shanghai). 2010 Oct;42(10):745-53. doi: 10.1093/abbs/gmq074. Epub 2010 Aug 27.
Ref 7 Mechanism of Action and Structure-Activity Relationship of -Conotoxin Mr1.1 at the Human 910 Nicotinic Acetylcholine Receptor. J Med Chem. 2022 Dec 22;65(24):16204-16217. doi: 10.1021/acs.jmedchem.2c00494. Epub 2022 Sep 22.
Ref 8 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 9 Globular and ribbon isomers of Conus geographus -conotoxins antagonize human nicotinic acetylcholine receptors. Biochem Pharmacol. 2021 Aug;190:114638. doi: 10.1016/j.bcp.2021.114638. Epub 2021 May 29.
Ref 10 Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom. Biochemistry. 2017 Nov 14;56(45):6051-6060. doi: 10.1021/acs.biochem.7b00485. Epub 2017 Nov 1.
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