Peptide Information

General Information of This Peptide
Peptide ID
BTDP008337
Peptide Name
Alpha-conotoxin G1.5
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CAI15_CONGE
Alphafold ID
X5I9Z2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: X5I9Z2
Sequence
MGMRMMFTVFLLVALATTVVSFTSDRASDRRNAAVKAFDLISSTVKKGCCSHPACSGNNP
EYCRQGR
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Sequence Length
67
Mass (Da)
7306
Signal Sequence
MGMRMMFTVFLLVALATTVVS
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Sequence Removed Signal Peptide
FTSDRASDRRNAAVKAFDLISSTVKKGCCSHPACSGNNPEYCRQGR
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Disulfide Bond
49-55;50-63
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
35.7 nM
 .
By globular isomer
 [1], [2]
 Target Info    nAChR alpha-9-alpha-10 IC50
569 nM
 .
By globular isomer
 [1], [2]
 Target Info    nAChR alpha-3-beta-4 IC50
1.928 μM
 .
By globular isomer
 [1], [2]
 Target Info    nAChR alpha-7 IC50
1.935 μM
 .
By globular isomer
 [1], [2]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 Globular and ribbon isomers of Conus geographus -conotoxins antagonize human nicotinic acetylcholine receptors. Biochem Pharmacol. 2021 Aug;190:114638. doi: 10.1016/j.bcp.2021.114638. Epub 2021 May 29.
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