Peptide Information

General Information of This Peptide
Peptide ID
BTDP007424
Peptide Name
Alpha-conotoxin Mr1.1
Species
Conus marmoreus (Marble cone)
Uniprot Name
CA11_CONMR
Alphafold ID
Q6PTD1
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q6PTD1
Sequence
MGMRMMFTVFLLVVLATTVVSFTSDRASDGRKAAAKDKASDLVALTVKGCCSHPACSVNN
PDICG
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Sequence Length
65
Mass (Da)
6810
Signal Sequence
MGMRMMFTVFLLVVLATTVVS
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Sequence Removed Signal Peptide
FTSDRASDGRKAAAKDKASDLVALTVKGCCSHPACSVNNPDICG
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Disulfide Bond
50-56;51-64
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus marmoreus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 Inhibition rate
50 - 70 %
10 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-3-beta-4 Inhibition rate
60 %
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-7 Inhibition rate
65 %
1 μM
 . [1], [2], [3]
 Target Info    nAChR alpha-9-alpha-10 IC50
8.3 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-9-alpha-10 IC50
92 nM
 . . [1], [2], [3]
 Target Info    nAChR alpha-3-beta-2 IC50
218.9 nM
 . . [1], [2], [3]
References
Ref 1 From the identification of gene organization of alpha conotoxins to the cloning of novel toxins. Toxicon. 2007 Jun 15;49(8):1135-49. doi: 10.1016/j.toxicon.2007.02.011. Epub 2007 Mar 1.
Ref 2 Chemical synthesis and characterization of two 4/7-conotoxins. Acta Biochim Biophys Sin (Shanghai). 2010 Oct;42(10):745-53. doi: 10.1093/abbs/gmq074. Epub 2010 Aug 27.
Ref 3 Mechanism of Action and Structure-Activity Relationship of -Conotoxin Mr1.1 at the Human 910 Nicotinic Acetylcholine Receptor. J Med Chem. 2022 Dec 22;65(24):16204-16217. doi: 10.1021/acs.jmedchem.2c00494. Epub 2022 Sep 22.
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