Peptide Information

General Information of This Peptide
Peptide ID
BTDP001542
Peptide Name
Alpha-conotoxin GeXXA
Symonym
Alpha-D-conotoxin GeXXA; Ge-5
Species
Conus generalis (General cone)
Uniprot Name
CDKA_CONGR
Alphafold ID
A0A0A0VBX4
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 4X9Z
Sequence
MPKQEKMMLVLLILPLPYCNAAGVTTVQWGGHGDGLDRYLQRGVRDVHRPCQSVRPGRVW
GKCCLTRLCSTMCCARADCTCVYHTWRGHGCSCVM
   Click to Show/Hide
Sequence Length
95
Mass (Da)
10644
Signal Sequence
MPKQEKMMLVLLILPLPYCNA
   Click to Show/Hide
Sequence Removed Signal Peptide
AGVTTVQWGGHGDGLDRYLQRGVRDVHRPCQSVRPGRVWGKCCLTRLCSTMCCARADCTC
VYHTWRGHGCSCVM
   Click to Show/Hide
Disulfide Bond
51;63;64-73;69-81;74-91;79-93
PDB ID
4X9Z
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus generalis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-9-alpha-10 IC50
1.2 nM
 . . [1], [2]
 Target Info    nAChR alpha-9-alpha-10 IC50
28 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
210 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
498 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-4 IC50
614 nM
 . . [1], [2]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
743 nM
 . . [1], [2]
References
Ref 1 Conotoxin D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep. 2015 Sep 23;5:14261. doi: 10.1038/srep14261.
Ref 2 High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. Mar Drugs. 2019 Mar 26;17(3):193. doi: 10.3390/md17030193.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.