Peptide Information

General Information of This Peptide
Peptide ID
BTDP008726
Peptide Name
Potassium channel toxin alpha-KTx 3.6
Symonym
BmKTX
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KAX36_MESMA
Alphafold ID
Q9NII7
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1BKT
Sequence
MKVFFAVLITLFICSMIIGIHGVGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPKG
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Sequence Length
60
Mass (Da)
6462
Sequence Removed Signal Peptide
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPK
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Disulfide Bond
29-49;35-54;39-56
PDB ID
1BKT , 2K4U , 2MLA , 2MLD
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv3.1 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv4.3 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
2 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
>0 %
2 μM
Blocker
 [1- 5]
 Target Info    Kv1.3 Inhibition rate
>0 %
2 μM
Blocker
 [1- 5]
 Target Info    Shaker Inhibition rate
21 %
2 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate
73 %
2 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate
91 %
2 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
100 %
2 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate
100 %
2 μM
Blocker
 [1]
 Target Info    Kv1 IC50
0.2 nM
 .
Blocker
 [1- 25]
References
Ref 1 A potent potassium channel blocker from Mesobuthus eupeus scorpion venom. Biochimie. 2010 Dec;92(12):1847-53. doi: 10.1016/j.biochi.2010.08.003. Epub 2010 Aug 14.
Ref 2 Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):805-9.
Ref 3 Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels. Biochemistry. 1997 Nov 4;36(44):13473-82. doi: 10.1021/bi971044w.
Ref 4 Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin. J Biol Chem. 2016 Mar 25;291(13):7097-106. doi: 10.1074/jbc.M115.680611. Epub 2016 Jan 27.
Ref 5 Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus Martensi. Proteins. 2000 Jan 1;38(1):70-8. doi: 10.1002/(sici)1097-0134(20000101)38:1<70::aid-prot8>3.0.co;2-5.
Ref 6 Modelling Alzheimer's disease in a dish: dissecting amyloid- metabolism in human neurons. Neuronal Signal. 2024 Jan 11;8(1):NS20230020. doi: 10.1042/NS20230020. eCollection 2024 Jan.
Ref 7 A commentary on the paper, 'Development and validation of a novel automatable assay for cholesterol efflux capacity'. Biosci Rep. 2023 Jun 28;43(6):BSR20230124. doi: 10.1042/BSR20230124.
Ref 8 Retracted: Chen, Y, Zhang, W, Kadier, A, Zhang, H, Yao, X. MicroRNA-769-5p suppresses cell growth and migration via targeting NUSAP1 in bladder cancer. J Clin Lab Anal. 2020; 34:e23193. J Clin Lab Anal. 2023 Apr;37(8):e24893. doi: 10.1002/jcla.24893. Epub 2023 May 14.
Ref 9 New mechanisms for the kidney-protective effect of alkali in chronic kidney disease. Clin Sci (Lond). 2022 Oct 28;136(20):1433-1437. doi: 10.1042/CS20220395.
Ref 10 ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis. Clin Sci (Lond). 2022 Sep 30;136(18):1367-1370. doi: 10.1042/CS20220394.
Ref 11 Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases. J Inflamm Res. 2022 May 25;15:3083-3094. doi: 10.2147/JIR.S350109. eCollection 2022.
Ref 12 Angiotensin receptors - affinitiy and beyond. Clin Sci (Lond). 2022 May 27;136(10):799-802. doi: 10.1042/CS20220024.
Ref 13 Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis. Clin Sci (Lond). 2022 May 27;136(10):711-714. doi: 10.1042/CS20211175.
Ref 14 SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection. Clin Sci (Lond). 2022 Mar 31;136(6):431-434. doi: 10.1042/CS20220028.
Ref 15 Microbiota transplantation in portal hypertension: promises and pitfalls. Clin Sci (Lond). 2022 Mar 31;136(6):425-429. doi: 10.1042/CS20220029.
Ref 16 Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?. Clin Sci (Lond). 2022 Mar 18;136(5):379-382. doi: 10.1042/CS20211096.
Ref 17 MicroRNAs as messengers of liver diseases: has the message finally been decrypted?. Clin Sci (Lond). 2022 Mar 18;136(5):323-328. doi: 10.1042/CS20211177.
Ref 18 Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension. Clin Sci (Lond). 2022 Jan 14;136(1):163-166. doi: 10.1042/CS20211095.
Ref 19 A commentary on the paper: 'Evaluation of spice and herb as phytoderived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method'. Biosci Rep. 2022 Jan 28;42(1):BSR20211522. doi: 10.1042/BSR20211522.
Ref 20 Countering the classical renin-angiotensin system. Clin Sci (Lond). 2021 Dec 10;135(23):2619-2623. doi: 10.1042/CS20211043.
Ref 21 Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers. Biosci Rep. 2021 Dec 22;41(12):BSR20211096. doi: 10.1042/BSR20211096.
Ref 22 Double agent indole-3-acetic acid: mechanistic analysis of indole-3-acetaldehyde dehydrogenase AldA that synthesizes IAA, an auxin that aids bacterial virulence. Biosci Rep. 2021 Aug 27;41(8):BSR20210598. doi: 10.1042/BSR20210598.
Ref 23 Targeting the 'garbage-bin' to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU. Biosci Rep. 2021 Aug 27;41(8):BSR20210952. doi: 10.1042/BSR20210952.
Ref 24 Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?. Clin Sci (Lond). 2021 Jul 16;135(13):1627-1630. doi: 10.1042/CS20210227.
Ref 25 Promyelocytic leukemia protein: an atherosclerosis suppressor protein?. Clin Sci (Lond). 2021 Jul 16;135(13):1557-1561. doi: 10.1042/CS20210314.
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