Peptide Information

General Information of This Peptide
Peptide ID
BTDP008653
Peptide Name
Toxin VmKTx1
Symonym
Toxin sVmKTx
Species
Vaejovis mexicanus smithi (Mexican scorpion) (Vaejovis smithi)
Uniprot Name
KA23N_VAEMS
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MKTSCLLTILLLSFLVAVAVAEGERSARAAAISCVGSPECPPKCRAQGCKNGKCMNRKCK
CYYCG
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Sequence Length
65
Mass (Da)
6904
Signal Sequence
MKTSCLLTILLLSFLVAVAVA
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Sequence Removed Signal Peptide
EGERSARAAAISCVGSPECPPKCRAQGCKNGKCMNRKCKCYYCG
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Disulfide Bond
34-54;40-59;44-61;49-64
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Vaejovidae
Genus: Vaejovis
Species: Vaejovis smithi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.77 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
0.77 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 Dissociation constant
7.1 μM
 .
Blocker
 [1]
 Target Info    Kv1.2 Dissociation constant
7.1 μM
 .
Blocker
 [1], [2]
 Target Info    KCa3.1 Inhibition rate .
2.5 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
2.5 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv2.1 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
100 nM
Blocker
 [1]
References
Ref 1 sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity. Biochem Pharmacol. 2022 May;199:115023. doi: 10.1016/j.bcp.2022.115023. Epub 2022 Mar 28.
Ref 2 Transcriptome analysis of scorpion species belonging to the Vaejovis genus. PLoS One. 2015 Feb 6;10(2):e0117188. doi: 10.1371/journal.pone.0117188. eCollection 2015.
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