Peptide Information

General Information of This Peptide
Peptide ID
BTDP008628
Peptide Name
Potassium channel toxin alpha-KTx 3.11
Symonym
OdK2
Species
Odontobuthus doriae (Yellow Iranian scorpion)
Uniprot Name
KAX3B_ODODO
Alphafold ID
P0C909
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C909
Sequence
GVPTDVKCRGSPQCIQPCKDAGMRFGKCMNGKCHCTPK
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Sequence Length
38
Mass (Da)
4083
Sequence Removed Signal Peptide
GVPTDVKCRGSPQCIQPCKDAGMRFGKCMNGKCHCTPK
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Disulfide Bond
8-28;14-33;18-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Odontobuthus
Species: Odontobuthus doriae
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
35 nM
Blocker
 [1]
 Target Info    Kv1.3 IC50
7.2 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
7.2 nM
 .
Blocker
 [1], [2]
References
Ref 1 OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae. Toxicon. 2008 Jun 15;51(8):1424-30. doi: 10.1016/j.toxicon.2008.03.027. Epub 2008 Mar 29.
Ref 2 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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