Peptide Information

General Information of This Peptide
Peptide ID
BTDP008611
Peptide Name
Potassium channel toxin alpha-KTx 12.2
Symonym
Butantoxin; TtBut
Species
Tityus trivittatus (Argentinean scorpion)
Uniprot Name
KA122_TITTR
Alphafold ID
P0C168
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C168
Sequence
WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
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Sequence Length
40
Mass (Da)
4514
Sequence Removed Signal Peptide
WCSTCLDLACGASRECYDPCFKAFGRAHGKCMNNKCRCYT
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Disulfide Bond
2-5;10-31;16-36;20-38
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Tityus
Species: Tityus trivittatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker Dissociation constant
660 nM
 .
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv7.1 Inhibition rate
5 %
1 μM
Blocker
 [3]
 Target Info    Kv1 Inhibition rate
9 %
1 μM
Blocker
 [3]
 Target Info    Kv11 Inhibition rate
11 %
1 μM
Blocker
 [3]
 Target Info    Kv7.2 Inhibition rate
14 %
1 μM
Blocker
 [3]
 Target Info    Kv1.6 Inhibition rate
20 %
1 μM
Blocker
 [3]
 Target Info    Kv1.5 Inhibition rate
25 %
1 μM
Blocker
 [3]
 Target Info    Kv1.3 IC50
0.55 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 IC50
6.19 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1 IC50
46 nM
 .
Blocker
 [1], [2]
References
Ref 1 Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus. Toxicon. 2003 Feb;41(2):173-9. doi: 10.1016/s0041-0101(02)00247-7.
Ref 2 NMR solution structure of butantoxin. Arch Biochem Biophys. 2000 Jul 1;379(1):18-27. doi: 10.1006/abbi.2000.1858.
Ref 3 Electrophysiological characterization of Ts6 and Ts7, K? channel toxins isolated through an improved Tityus serrulatus venom purification procedure. Toxins (Basel). 2014 Feb 28;6(3):892-913. doi: 10.3390/toxins6030892.
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