Peptide Information

General Information of This Peptide
Peptide ID
BTDP008586
Peptide Name
Potassium channel toxin alpha-KTx 3.19
Symonym
Toxin MeKTx13-3
Species
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Uniprot Name
KAX3J_MESEU
Alphafold ID
C0HJQ6
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJQ6
Sequence
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPK
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Sequence Length
37
Mass (Da)
3969
Sequence Removed Signal Peptide
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPK
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Disulfide Bond
7-27;13-32;17-34
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus eupeus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1 IC50
1.9 nM
 .
Blocker
 [2]
 Target Info    Kv1 IC50
1.9 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
8.9 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
8.9 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.6 IC50
63.4 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.6 IC50
63.4 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
105.9 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.2 IC50
106 nM
 .
Blocker
 [1]
References
Ref 1 Tuning Scorpion Toxin Selectivity: Switching From K(V)1.1 to K(V)1.3. Front Pharmacol. 2020 Jul 7;11:1010. doi: 10.3389/fphar.2020.01010. eCollection 2020.
Ref 2 Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY. J Biol Chem. 2015 May 8;290(19):12195-209. doi: 10.1074/jbc.M115.637611. Epub 2015 Mar 19.
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