Peptide Information

General Information of This Peptide

Peptide ID	BTDP008575
Peptide Name	Kappa-LhTx-1
Species	Pandercetes sp. SD662
Uniprot Name	A0A8F4X4H7_9ARAC
3D Structure	Download 2D Sequence Download FASTA 3D Structure Download PDB Source Predict by Alphafold2 ? Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence	MKIFVAMMLVFVAFSAVAMAELSIQDAALDLLVAREDAQECASWMNLCGEKKCCEGYVCQ IWCKYKLG Click to Show/Hide
Sequence Length	68
Mass (Da)	7589
Sequence Removed Signal Peptide	ELSIQDAALDLLVAREDAQECASWMNLCGEKKCCEGYVCQIWCKYKLG Click to Show/Hide
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Arthropoda Class: Arachnida Order: Araneae Family: Sparassidae Genus: Pandercetes Species: Pandercetes sp. SD662

Full List of Activity Data of This Peptide Toxin

Target Name	Activity Data Type	Activity Data	Concentration	Note	Reference
Target Info Kv1.1	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv1.4	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv2.1	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv1.3	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv1.5	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv3.1	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv3.4	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv3.3	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv3.2	Inhibition rate	.	100 μM	Blocker	[1]
Target Info Kv4.2	IC50	140 nM	.	Blocker	[1]
Target Info Kv4.3	IC50	160 nM	.	Blocker	[1]
Target Info Kv4.1	IC50	870 nM	.	Blocker	[1]

References

Ref 1	Variation of Two S3b Residues in K(V)4.1-4.3 Channels Underlies Their Different Modulations by Spider Toxin -LhTx-1. Front Pharmacol. 2021 Jun 10;12:692076. doi: 10.3389/fphar.2021.692076. eCollection 2021.

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