Peptide Information

General Information of This Peptide
Peptide ID
BTDP008571
Peptide Name
Defensin BmKDfsin3
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
DEF3_MESMA
Alphafold ID
A0A384E0Y8
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 5XA6
Sequence
MKTIVILFVLALVFCTLEMGMVEAGFGCPFNQGKCHRHCRSIRRRGGYCDGFLKQRCVCY
RK
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Sequence Length
62
Mass (Da)
7149
Signal Sequence
MKTIVILFVLALVFCTLEMGMVEA
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Sequence Removed Signal Peptide
GFGCPFNQGKCHRHCRSIRRRGGYCDGFLKQRCVCYRK
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Disulfide Bond
28-49;35-57;39-59
PDB ID
5XA6
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate
15 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv1.2 Inhibition rate
28 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv11 Inhibition rate
30 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv11.1 Inhibition rate
30.4 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv1.1 Inhibition rate
57 %
1 μM
Blocker
 [1], [2]
 Target Info    KCa2.3 Inhibition rate
88 %
1 μM
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
23.4 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
23.4 nM
 .
Blocker
 [1], [2]
References
Ref 1 The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun. 2013;4:2602. doi: 10.1038/ncomms3602.
Ref 2 Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights origin of neurotoxins in telson formed in Paleozoic scorpions. Int J Biol Macromol. 2020 Apr 1;148:351-363. doi: 10.1016/j.ijbiomac.2020.01.133. Epub 2020 Jan 15.
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