Peptide Information

General Information of This Peptide
Peptide ID
BTDP008517
Peptide Name
Potassium channel toxin alpha-KTx 8.2
Symonym
Neurotoxin BmP01
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KAX82_MESMA
Alphafold ID
Q9U8D2
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1WM7
Sequence
MSRLYAIILIALVFNVVMTITPDMKVEAATCEDCPEHCATQNARAKCDNDKCVCEPK
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Sequence Length
57
Mass (Da)
6318
Sequence Removed Signal Peptide
MSRLYAIILIALVFNVVMTITPDMKVEAATCEDCPEHCATQNARAKCDNDKCVCEPK
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Disulfide Bond
31-47;34-52;38-54
PDB ID
1WM7
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
3 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate
4 %
10 μM
At 20°C
 [1- 6]
 Target Info    KCa2 Inhibition rate
4 %
1 μM
Blocker
 [4]
 Target Info    Shaker Inhibition rate
70 %
3 μM
Blocker
 [1]
 Target Info    Kv1 Inhibition rate
100 %
3 μM
At 20°C
 [1- 6]
 Target Info    capsaicin receptor TRPV1 Effective concentration 50
132 μM
 .
At 20°C
 [1- 6]
 Target Info    Kv1.3 IC50
133 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
269 - 467 nM
 .
At 20°C
 [1- 6]
 Target Info    Kv1.3 IC50
269 - 467 nM
 .
At 20°C
 [1- 6]
 Target Info    Kv1.3 IC50
269 - 467 nM
 .
At 20°C
 [1- 6]
 Target Info    Kv1 IC50
467 nM
 .
Blocker
 [1- 6]
References
Ref 1 Molecular diversity and functional evolution of scorpion potassium channel toxins. Mol Cell Proteomics. 2011 Feb;10(2):M110.002832. doi: 10.1074/mcp.M110.002832. Epub 2010 Sep 30.
Ref 2 Genomic organization of three neurotoxins active on small conductance Ca2+-activated potassium channels from the scorpion Buthus martensi Karsch. FEBS Lett. 1999 Jun 11;452(3):360-4. doi: 10.1016/s0014-5793(99)00651-1.
Ref 3 Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel. Toxins (Basel). 2015 Sep 14;7(9):3671-87. doi: 10.3390/toxins7093671.
Ref 4 Characterization of four toxins from Buthus martensi scorpion venom, which act on apamin-sensitive Ca2+-activated K+ channels. Eur J Biochem. 1997 Apr 15;245(2):457-64. doi: 10.1111/j.1432-1033.1997.00457.x.
Ref 5 Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch. Biochem Biophys Res Commun. 2000 Oct 5;276(3):1148-54. doi: 10.1006/bbrc.2000.3435.
Ref 6 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
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